IL1B / IL-1 beta Protein & Antibody (IL1F2)

Interleukin-1 beta (IL-1 family member 2)

IL-1 beta Products

IL-1 beta Protein, Recombinant

Molecule	Species	Description	Cat. No
IL-1 beta/IL-1F2	Human	IL-1 beta/IL-1F2 Protein, Recombinant	10139-HNAE
IL-1 beta/IL-1F2	Human	IL-1 beta/IL-1F2 (pro form) Protein, Recombinant	10139-H07E
IL-1 beta/IL-1F2	Mouse	IL-1 beta/IL-1F2 Protein, Recombinant	50101-MNAE
IL-1 beta/IL-1F2	Rat	IL-1 beta/IL-1F2 (mature form) Protein, Recombinant, Native	80023-RNAE
IL-1 beta/IL-1F2	Rat	IL-1 beta/IL-1F2 (pro form) Protein, Recombinant	80023-R07E
IL-1 beta/IL-1F2	Canine	IL1B / IL-1beta Protein,Recombinant, Native	70018-DNAE
IL-1 beta/IL-1F2	Cynomolgus	IL1B / IL-1beta Protein, Recombinant, Native	90010-CNAE

  10139-HNAE:

1. Immobilized recombinant human IL1B at 2 µg/mL (100µl/well) can bind recombinant human  IL1R2 with a linear  range of  6.25-400 ng/ml. Measured by its binding ability in a functional ELISA.

2. The ED₅₀ for this effect is typically 0.5-5 pg/mL. Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells.

  50101-MNAE: The ED₅₀ for this effect is typically 2-10 pg/mL. Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells.

IL-1 beta Antibody

Molecule	Application	Description	Cat. No
Human IL-1 beta/IL-1F2	WB, ELISA	IL-1 beta/IL-1F2 Antibody, Rabbit MAb	10139-R012
Human IL-1 beta/IL-1F2	WB, ELISA	IL-1 beta/IL-1F2 Antibody, Rabbit PAb	10139-RP01
Human IL-1 beta/IL-1F2	WB, ELISA	IL-1 beta/IL-1F2 Antibody, Rabbit PAb (Antigen Affinity Purified)	10139-RP02
Mouse IL-1 beta/IL-1F2	WB, ELISA	IL-1 beta Antibody (Antigen Affinity Purified)	50101-RP02
Rat IL-1 beta/IL-1F2	WB, ELISA	IL-1 beta/IL-1F2 Antibody, Rabbit PAb (Antigen Affinity Purified)	80023-RP02

IL-1 beta cDNA Clone

Molecule	Species	Description	Cat. No
IL-1 beta/IL-1F2	Human	Homo sapiens IL-1 beta/IL-1F2 cDNA Clone(NM_000576.2)	HG10139-M
IL-1 beta/IL-1F2	Mouse	Mus musculus IL-1 beta/IL-1F2 cDNA Clone	MG50101-M
IL-1 beta/IL-1F2	Canine	IL1B cDNA Clone / ORF Clone	CG70018-G
IL-1 beta/IL-1F2	Rat	Rattus norvegicus IL-1 beta/IL-1F2 cDNA Clone	RG80023-M
IL-1 beta/IL-1F2	Cynomolgus	Cynomolgus monkey IL-1 beta/IL-1F2/IL1B cDNA Clone / ORF Clone	KG90010-M

IL-1 beta Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1 beta/IL-1F2

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-1 beta/IL-1F2

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family >>IL-1 beta/IL-1F2

IL-1 beta Alternative Names

IL-1 beta, IL1F2, IL1B, IL-1, IL1-BETA

IL1B / IL1beta Background

Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).

IL1B / IL1beta Related Studies

1. Kim SH, et al. (2008) Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 14:2109-16.
2. Wang ZC, et al. (2002) T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 3(1): 38-42.
3. Mattuzzi S, et al. (2007) Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol. 34(5): 997-1004.