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IL-1 beta Protein, Antibody, ELISA Kit, cDNA Clone

Rabbit IL-1 beta Protein

Expression host: E. coli
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65004-TNAE-5
65004-TNAE-100
65004-TNAE-20
5 µg / $78
100 µg / $548
20 µg / $178
Add to Cart

Canine IL-1 beta Protein

Description: Active
Expression host: E. coli
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70018-DNAE-5
70018-DNAE-100
70018-DNAE-20
5 µg / $38
100 µg / $548
20 µg / $178
Add to Cart

Cynomolgus IL-1 beta Protein

Description: Active
Expression host: E. coli
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90010-CNAE-5
90010-CNAE-100
90010-CNAE-20
90010-CNAE-500
90010-CNAE-1
5 µg / $68
100 µg / $648
20 µg / $248
500 µg / $1948
1 mg / $3248
Add to Cart

Sus scrofa (Pig) IL-1 beta Protein

Expression host: E. coli
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62003-WNAE-20
62003-WNAE-5
62003-WNAE-10
20 µg / $248
5 µg / $98
10 µg / $138
Add to Cart

Mouse IL-1 beta Protein

Description: Active
Expression host: E. coli
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50101-MNAE-5
50101-MNAE-20
50101-MNAE-100
50101-MNAE-500
50101-MNAE-1
5 µg / $58
20 µg / $198
100 µg / $598
500 µg / $1898
1 mg / $2998
Add to Cart

Feline IL-1 beta Protein

Expression host: E. coli
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67002-UNAE-5
67002-UNAE-20
67002-UNAE-10
5 µg / $98
20 µg / $248
10 µg / $138
Add to Cart

Rat IL-1 beta Protein

Expression host: E. coli
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80023-R07E-20
80023-R07E-50
20 µg / $198
50 µg / $398
Add to Cart
Description: Active
Expression host: E. coli
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80023-RNAE-20
80023-RNAE-5
80023-RNAE-100
20 µg / $178
5 µg / $38
100 µg / $698
Add to Cart

Human IL-1 beta Protein

Description: Active
Expression host: E. coli
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10139-HNAE-100
10139-HNAE-500
10139-HNAE-5
10139-HNAE-1
10139-HNAE-20
100 µg / $598
500 µg / $1898
5 µg / $58
1 mg / $2998
20 µg / $198
Add to Cart
Description: Active
Expression host: E. coli
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10139-H07E-20
10139-H07E-50
20 µg / $138
50 µg / $298
Add to Cart

IL-1 beta Related Areas

IL-1 beta Related Pathways

IL-1 beta Related Product

IL-1 beta Summary & Protein Information

IL-1 beta Related Information

IL-1 beta Background

Gene Summary: The protein encoded by IL1B gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. IL1B gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
General information above from NCBI
Subunit structure: Monomer.
Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
Subcellular location: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Sequence similarity: Belongs to the IL-1 family.
General information above from UniProt

Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).

IL-1 beta Alternative Name

IL-1,IL-1 beta,IL1B,IL1-BETA,IL1F2, [human]

IL-1 beta Related Studies

  • Kim SH, et al. (2008) Association of -31TC and -511 CT polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 14:2109-16.
  • Wang ZC, et al. (2002) T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 3(1): 38-42.
  • Mattuzzi S, et al. (2007) Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol. 34(5): 997-1004.
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