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IL-1 beta / IL1B / IL1F2 Antibody, Rabbit MAb

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Human IL1B Antibody Product Information
Immunogen:Recombinant Human ILb protein (Catalog#10139-HNAE)
Clone ID:012
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human IL1B (rh IL1B; Catalog#10139-HNAE; NP_000567.1; Ala 117-Ser 269).
Human IL1B Antibody Usage Guide
Specificity:Human IL-1 beta / IL1B
No cross-reactivity in ELISA with
Human IL1A / IL1F1
Human IL1R2 / IL1RB
Application:ELISA

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL1b. The detection limit for Human IL1b is approximately 0.0049 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other IL1B Antibody Products
Reactivity: Human  
Application: ELISA  
    10139-RP01-400
    10139-RP01-100
    10139-RP01-200
     
    100 µg 
    200 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10139-RP02-200
      10139-RP02-50
      10139-RP02-100
      200 µg 
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  IHC-P  
      • Slide 1
      • Slide 1
      10139-M201-100
      10139-M201-50
      10139-M201-200
      100 µg 
      50 µg 
      200 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  
        50101-R020-50
        50101-R020-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50101-R001-50
          50101-R001-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50101-RP01-400
            50101-RP01-200
            50101-RP01-100
             
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  WB  
            • Slide 1
            50101-RP02-50
            50101-RP02-100
            50101-RP02-200
            50 µg 
            100 µg 
            200 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  WB  
            • Slide 1
            50101-T48-200
            50101-T48-100
            50101-T48-50
            200 µg 
            100 µg 
            50 µg 
            Add to Cart
            Reactivity: Rat  
            Application: ELISA  
              80023-T16-50
              80023-T16-100
              80023-T16-200
              50 µg 
              100 µg 
              200 µg 
              Add to Cart
              Reactivity: Rat  
              Application: ELISA  WB  
              • Slide 1
              80023-RP02-50
              80023-RP02-100
              80023-RP02-200
              50 µg 
              100 µg 
              200 µg 
              Add to Cart
              Reactivity: Rat  
              Application: ELISA  
                80023-RP01-100
                80023-RP01-200
                80023-RP01-400
                100 µg 
                200 µg 
                 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  
                  80023-R017-50
                  80023-R017-100
                  50 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Cynomolgus  
                  Application: ELISA  
                    90010-RP01-100
                    90010-RP01-400
                    90010-RP01-200
                    100 µg 
                     
                    200 µg 
                    Add to Cart
                    Reactivity: Cynomolgus  
                    Application: ELISA  IHC-P  
                    • Slide 1
                    90010-T24-100
                    90010-T24-200
                    90010-T24-50
                    100 µg 
                    200 µg 
                    50 µg 
                    Add to Cart
                    Reactivity: Canine  
                    Application: ELISA  WB  
                    • Slide 1
                    70018-T48-200
                    70018-T48-100
                    70018-T48-50
                    200 µg 
                    100 µg 
                    50 µg 
                    Add to Cart
                    Reactivity: Canine  
                    Application: ELISA  
                      70018-RP01-400
                      70018-RP01-200
                      70018-RP01-100
                       
                      200 µg 
                      100 µg 
                      Add to Cart
                      Reactivity: Sus scrofa (Pig)  
                      Application: ELISA  
                        62003-T16-200
                        62003-T16-50
                        62003-T16-100
                        200 µg 
                        50 µg 
                        100 µg 
                        Add to Cart
                        Reactivity: Sus scrofa (Pig)  
                        Application: ELISA  
                          62003-RP01-400
                          62003-RP01-200
                          62003-RP01-100
                           
                          200 µg 
                          100 µg 
                          Add to Cart
                          Reactivity: Feline  
                          Application: ELISA  
                            67002-T16-100
                            67002-T16-50
                            67002-T16-200
                            100 µg 
                            50 µg 
                            200 µg 
                            Add to Cart
                            Reactivity: Feline  
                            Application: ELISA  
                              67002-RP01-400
                              67002-RP01-200
                              67002-RP01-100
                               
                              200 µg 
                              100 µg 
                              Add to Cart
                              IL1B/IL-1B/IL-1 beta Background

                              Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).

                              Human IL1B/IL-1B/IL-1 beta References
                            • Kim SH, et al. (2008) Association of -31TC and -511 CT polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 14:2109-16.
                            • Wang ZC, et al. (2002) T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 3(1): 38-42.
                            • Mattuzzi S, et al. (2007) Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol. 34(5): 997-1004.
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                              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"