IL-1 alpha Protein (IL-1F1,IL1A Protein)

Interleukin-1 alpha (IL-1 family member 1)

IL-1 alpha Products

IL-1 alpha Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-1 alpha/IL-1F1	Human	IL-1 alpha/IL-1F1 Protein, Recombinant	10128-HNCH
IL-1 alpha/IL-1F1	Mouse	IL-1 alpha/IL-1F1 Protein, Recombinant	50114-MNAE

  10128-HNCH: The ED₅₀ for this effect is typically 0.1-0.5 pg/mL. Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells.

  50114-MNAE: The ED₅₀ for this effect is typically 2-10 pg/mL. Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells.

IL-1 alpha cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-1 alpha/IL-1F1	Human	Homo sapiens IL-1 alpha/IL-1F1 cDNA Clone(NM_000575.3)	HG10128-M
IL-1 alpha/IL-1F1	Mouse	Mus musculus IL-1 alpha/IL-1F1 cDNA Clone	MG50114-M
IL-1 alpha/IL-1F1	Canine	IL1A cDNA Clone / ORF Clone	CG70017-G
IL-1 alpha/IL-1F1	Rat	IL1A cDNA Clone / ORF Clone	RG80385-G
IL-1 alpha/IL-1F1	Cynomolgus	IL1A cDNA Clone / ORF Clone	KG90124-G

IL-1 alpha Alternative Names

IL-1 alpha, IL1F1, IL1A, IL-1A, IL1, IL1-ALPHA

IL-1 alpha Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1 alpha/IL-1F1

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 superfamily and IL-1R/TLR family>>IL-1 alpha/IL-1F1

IL-1 alpha Background

IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.

IL-1 alpha Related Studies

1. Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
2. March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
3. Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
4. Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.