All IL-1 alpha reagents are produced in house and quality controlled, including 10 IL-1 alpha Antibody, 2 IL-1 alpha ELISA, 65 IL-1 alpha Gene, 1 IL-1 alpha IPKit, 1 IL-1 alpha Lysate, 2 IL-1 alpha Protein, 3 IL-1 alpha qPCR. All IL-1 alpha reagents are ready to use.
Recombinant IL-1 alpha proteins are expressed by E. coli, HEK293 Cells with fusion tags as Native, N-human IgG1-Fc, N-cleavage.
IL-1 alphaantibodies are validated with different applications, which are ELISA, IHC-P, WB, IP, ELISA(Cap).
IL-1 alphacDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL-1 alpha of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
IL-1 alphaELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.