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IL1A/IL-1A/IL-1F1  Protein, Antibody, ELISA Kit, cDNA Clone

Description: Active  
Expression host: Human Cells  
10128-HNCH-5
10128-HNCH-20
10128-HNCH-100
5 µg 
20 µg 
100 µg 
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  • Slide 1
Description: Active  
Expression host: E. coli  
50114-MNAE-5
50114-MNAE-20
50114-MNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1

IL1A/IL-1A/IL-1F1 Related Area

IL1A/IL-1A/IL-1F1 Related Pathways

IL1A/IL-1A/IL-1F1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

IL1A/IL-1A/IL-1F1 Summary & Protein Information

IL1A/IL-1A/IL-1F1 Background

Gene Summary: The IL-1 alpha protein encoded by this IL1A gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This IL-1 alpha cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
General information above from NCBI
Subunit structure: Monomer.
Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
Subcellular location: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Sequence similarity: Belongs to the IL-1 family. {ECO:0000305}.
General information above from UniProt

IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

IL1A/IL-1A/IL-1F1 Alternative Name

IL-1F1,Il-1a, []
IL1,IL-1A,IL1F1,IL1-ALPHA, [homo-sapiens]
IL1,IL-1 alpha,IL1A,IL-1A,IL1-ALPHA,IL1F1, [human]
Il-1a, [mus-musculus]

IL1A/IL-1A/IL-1F1 Related Studies

  • Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
  • March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
  • Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
  • Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.
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