Anti-IL-1 alpha Antibody

Cat: 50114-RP02
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All IL-1 alpha Reagents
Anti-IL-1 alpha Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL-1 alpha Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse IL-1 alpha
Immunogen
Recombinant Mouse IL-1 alpha / IL-1F1 / IL1A protein (Catalog#50114-MNAE)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse IL-1 alpha / IL-1F1 / IL1A (rM IL-1 alpha / IL-1F1 / IL1A; Catalog#50114-MNAE; NP_034684.2; Ser 115-Ser 270). IL-1 alpha / IL-1F1 / IL1A specific IgG was purified by Mouse IL-1 alpha / IL-1F1 / IL1A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL-1 alpha Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:250-1:1000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-1 alpha Antibody (Rabbit Polyclonal antibody) Images
Mouse IL1A/IL-1A/IL-1F1 Immunohistochemistry(IHC) 3260
Immunochemical staining of mouse IL1A in mouse-brain with rabbit polyclonal antibody (1:500, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-IL-1 alpha Antibody Alternative Names
Anti-Il-1a Antibody
IL-1 alpha Background Information

IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 1, alpha
References
  • Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
  • March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
  • Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
  • Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL-1 alpha Antibody Rabbit Polyclonal WB 50114-T32
    Anti-IL-1 alpha Antibody Rabbit Polyclonal IHC-P 105996-T08
    Anti-IL-1 alpha Antibody Rabbit Polyclonal ELISA 50114-T16
    Anti-IL-1 alpha Antibody Rabbit Polyclonal WB,ELISA,IP 50114-T52
    Anti-IL-1 alpha Antibody Rabbit Monoclonal ELISA(Cap) 50114-R148
    Anti-IL-1 alpha Antibody Rabbit Polyclonal ELISA 50114-RP01
    Anti-IL-1 alpha Antibody Rabbit Monoclonal ELISA 50114-R024
    Anti-IL-1 alpha Antibody Rabbit Polyclonal ELISA 10128-RP01
    Anti-IL-1 alpha Antibody Rabbit Polyclonal ELISA 10128-T16
    Anti-IL-1 alpha Antibody Rabbit Monoclonal ELISA 10128-R004
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