Anti-IL-1 alpha Antibody

Cat: 50114-RP02
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All IL-1 alpha Reagents
Anti-IL-1 alpha Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL-1 alpha Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse IL-1 alpha
Recombinant Mouse IL-1 alpha / IL-1F1 / IL1A protein (Catalog#50114-MNAE)
Produced in rabbits immunized with purified, recombinant Mouse IL-1 alpha / IL-1F1 / IL1A (rM IL-1 alpha / IL-1F1 / IL1A; Catalog#50114-MNAE; NP_034684.2; Ser 115-Ser 270). IL-1 alpha / IL-1F1 / IL1A specific IgG was purified by Mouse IL-1 alpha / IL-1F1 / IL1A affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL-1 alpha Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:250-1:1000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-1 alpha Antibody (Rabbit Polyclonal antibody) Images
Mouse IL1A/IL-1A/IL-1F1 Immunohistochemistry(IHC) 3260
Immunochemical staining of mouse IL1A in mouse-brain with rabbit polyclonal antibody (1:500, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-IL-1 alpha Antibody Alternative Names
Anti-Il-1a Antibody
IL-1 alpha Background Information

IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 1, alpha
  • Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
  • March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
  • Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
  • Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL-1 alpha Antibody Rabbit Polyclonal WB 50114-T32
    Anti-IL-1 alpha Antibody Rabbit Polyclonal IHC-P 105996-T08
    Anti-IL-1 alpha Antibody Rabbit Polyclonal ELISA 50114-T16
    Anti-IL-1 alpha Antibody Rabbit Polyclonal WB,ELISA,IP 50114-T52
    Anti-IL-1 alpha Antibody Rabbit Monoclonal ELISA(Cap) 50114-R148
    Anti-IL-1 alpha Antibody Rabbit Polyclonal ELISA 50114-RP01
    Anti-IL-1 alpha Antibody Rabbit Monoclonal ELISA 50114-R024
    Anti-IL-1 alpha Antibody Rabbit Polyclonal ELISA 10128-RP01
    Anti-IL-1 alpha Antibody Rabbit Polyclonal ELISA 10128-T16
    Anti-IL-1 alpha Antibody Rabbit Monoclonal ELISA 10128-R004
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