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IGSF3 Protein, Antibody, ELISA Kit, cDNA Clone

IGSF3 Related Areas

IGSF3 Related Pathways

IGSF3 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    IGSF3 Summary & Protein Information

    IGSF3 Background

    Gene Summary: By fluorescence in situ hybridization and somatic cell hybrid analyses, Saupe et al. (1998) localized the human IGSF3 gene to 1p13 and demonstrated the presence of related sequences on chromosomes 2 and 13.
    General information above from NCBI
    Subcellular location: Membrane; Single-pass type I membrane protein (Potential).
    Tissue specificity: Expressed in a wide range of tissues with High expression in Placenta, kidney and lung.
    Sequence similarity: Contains 8 Ig-like C2-type (immunoglobulin-like) domains.
    General information above from UniProt

    Immunoglobulin superfamily member 3 (IGSF3), also known as Glu-Trp-Ile EWI motif-containing protein 3, IgSF3 and EWI-3 and IGSF3, is a single-pass type I membrane protein which belongs to the EWI subfamily of the Ig Superfamily of molecules. IGSF3 has an overall structural similarity and strong sequence similarity to V7, a human leukocyte surface protein. IGSF3 contains eight Ig-like C2-type (immunoglobulin-like) domains. IGSF3 is expressed in a wide range of tissues with high expression in Placenta, kidney and lung. EWI-2 is part of a novel Ig subfamily that includes EWI-F (F2alpha receptor regulatory protein (FPRP), CD9P-1 ), EWI-3 (IGSF3), and EWI-101 (CD101). All four members of this Ig subfamily contain a Glu-Trp-Ile (EWI) motif not seen in other Ig proteins. Human IGSF3 shares 92 % aa identity with mouse IGSF3.

    IGSF3 Alternative Name

    V8,LCDD,EWI-3, [homo-sapiens]
    EWI-3,IGSF3,MGC117164,RP4-781D12.1,V8, [human]
    1700016K10Rik,2810035F16Rik,4833439O17Rik,Igsf3,mKIAA0466, [mouse]
    mKIAA0466,1700016K10Rik,2810035F16Rik,4833439O17Rik, [mus-musculus]

    IGSF3 Related Studies

  • Saupe S, et al. (1998) Molecular cloning of a human cDNA IGSF3 encoding an immunoglobulin-like membrane protein: expression and mapping to chromosome band 1p13. Genomics. 52(3): 305-11.
  • Lazaar AL, et al. (2001) VCAM-1 activates phosphatidylinositol 3-kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells. J Immunol. 166(1): 155-61.
  • Wetzel A, et al. (2004) Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Immunol. 172(6): 3850-9.