IGSF3 Protein & Antibody

Immunoglobulin superfamily, member 3

IGSF3 Products

IGSF3 Protein, Recombinant

Molecule	Species	Description	Cat. No
IGSF3	Human	IGSF3 Protein, Recombinant	11290-H08H

IGSF3 Antibody

Molecule	Application	Description	Cat. No
Human IGSF3	WB, ELISA	IGSF3 Antibody (Antigen Affinity Purified)	11290-RP02

IGSF3 cDNA Clone

Molecule	Species	Description	Cat. No
IGSF3	Human	Human IGSF3 cDNA Clone / ORF Clone	HG11290-M

IGSF3 Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>IGSF3

IGSF3 Alternative Names

IGSF3, RP4-781D12.1, EWI-3, MGC117164, V8 [Homo sapiens]

Igsf3, 1700016K10Rik, 2810035F16Rik, 4833439O17Rik, mKIAA0466 [Mus musculus]

IGSF3 Background

Immunoglobulin superfamily member 3 (IGSF3), also known as Glu-Trp-Ile EWI motif-containing protein 3, IgSF3 and EWI-3 and IGSF3, is a single-pass type I membrane protein which belongs to the EWI subfamily of the Ig Superfamily of molecules. IGSF3 has an overall structural similarity and strong sequence similarity to V7, a human leukocyte surface protein. IGSF3 contains eight Ig-like C2-type (immunoglobulin-like) domains. IGSF3 is expressed in a wide range of tissues with high expression in Placenta, kidney and lung. EWI-2 is part of a novel Ig subfamily that includes EWI-F (F2alpha receptor regulatory protein (FPRP), CD9P-1 ), EWI-3 (IGSF3), and EWI-101 (CD101). All four members of this Ig subfamily contain a Glu-Trp-Ile (EWI) motif not seen in other Ig proteins. Human IGSF3 shares 92 % aa identity with mouse IGSF3.

IGSF3 Related Studies

1. Saupe S, et al. (1998) Molecular cloning of a human cDNA IGSF3 encoding an immunoglobulin-like membrane protein: expression and mapping to chromosome band 1p13. Genomics. 52(3): 305-11.
2. Lazaar AL, et al. (2001) VCAM-1 activates phosphatidylinositol 3-kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells. J Immunol. 166(1): 155-61.
3. Wetzel A, et al. (2004) Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Immunol. 172(6): 3850-9.