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IGSF11 Protein, Antibody, ELISA Kit, cDNA Clone

IGSF11 Related Areas

IGSF11 Related Pathways

IGSF11 Related Product

    IGSF11 Summary & Protein Information

    IGSF11 Background

    Gene Summary: IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).
    General information above from NCBI
    Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity).
    Tissue specificity: Abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.
    Post-translational: N-glycosylated (By similarity).
    Sequence similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.C
    General information above from UniProt

    Immunoglobulin superfamily member 11(IGSF11) are expressed on the plasma membrane in the tesis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to over expressed in colorectal cancers and hepatocellular carcinomas as well as intestinal-type gastric cancers compared to their corresponding non- cancerous tissues. The IGSF11 has also been found expressed abundantly in testis and ovary and the IGSF11 can be used as a candidate of cancer-testis antigen.

    IGSF11 Alternative Name

    BT-IgSF,CXADRL1,IGSF11,Igsf13,MGC35227,CT119,VSIG3, [human]
    1700025L02Rik,BT-IgSF,Igsf11,Igsf13,RP23-131M7.1, [mouse]

    IGSF11 Related Studies

  • Toshimori K, et al. (2006) The involvement of immunoglobulin superfamily proteins in spermatogenesis and sperm-egg interaction. Reproductive Medicine and Biology. 5(2): 87-93.
  • Coyne CB, et al. (2005) CAR: A virus receptor within the tight junction. Advanced Drug Delivery Reviews. 57(6) : 869-82.
  • Watanabe T, et al. (2005) Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. Cancer Science. 96(8) :498-506.
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