IGSF11 Protein

Immunoglobulin superfamily, member 11

IGSF11 Products

IGSF11 Protein, Recombinant

Molecule	Species	Description	Cat. No
IGSF11	Human	IGSF11 Protein, Recombinant	13094-H08H

IGSF11 Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>IGSF11

IGSF11 Alternative Names

IGSF11, BT-IgSF, CT119, CXADRL1, Igsf13, MGC35227, VSIG3 [Homo sapiens]

Igsf11, RP23-131M7.1, 1700025L02Rik, BT-IgSF, Igsf13 [Mus musculus]

IGSF11 Background

Immunoglobulin superfamily member 11(IGSF11) are expressed on the plasma membrane in the tesis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to over expressed in colorectal cancers and hepatocellular carcinomas as well as intestinal-type gastric cancers compared to their corresponding non- cancerous tissues. The IGSF11 has also been found expressed abundantly in testis and ovary and the IGSF11 can be used as a candidate of cancer-testis antigen.

IGSF11 Related Studies

1. Toshimori K, et al. (2006) The involvement of immunoglobulin superfamily proteins in spermatogenesis and sperm–egg interaction. Reproductive Medicine and Biology. 5(2): 87-93.
2. Coyne CB, et al. (2005) CAR: A virus receptor within the tight junction. Advanced Drug Delivery Reviews. 57(6) : 869-82.
3. Watanabe T, et al. (2005) Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. Cancer Science. 96(8) :498-506.