Anti-IgJ Antibody (Rabbit Monoclonal antibody) General Information
Reacts with: Human
Recombinant Human IGJ protein (Catalog#13015-H08E)
This antibody was obtained from a rabbit immunized with purified, recombinant Human IGJ (Catalog#13015-H08E; NP_653247.1; Gln23-Asp159).
Monoclonal Rabbit IgG Clone #027
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IgJ Antibody (Rabbit Monoclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-IgJ Antibody Alternative Names
Anti-IGCJ Antibody;Anti-JCH Antibody
IgJ Background Information
Immunoglobulin J chain, also known as IGJ and IGCJ, is a secreted polypeptide which is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver. The joining Immunoglobulin J chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. Immunoglobulin J chain / IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. Immunoglobulin J chain / IGJ also help to bind these immunoglobulins to secretory component. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. Immunoglobulin J chain / IGJ is involved in creating the binding site for pIgR / SC in the Ig polymers, not only by determining the polymeric quaternary structure but apparently also by interacting directly with the receptor protein. Both the immunoglobulin J chain / IGJ and the pIgR/SC are key proteins in secretory immunity.
immunoglobulin joining chain
Zikan, J. et al., 1985, Proc Natl Acad Sci USA. 82 (17): 5905-9. Koshland, M.E. et al., 1985, Annu Rev Immunol. 3: 425-53. Iwase,T. et al., 1993, Cell Struct Funct. 18 (5): 297-302. Johansen, F.E. et al., 2000, Scand J Immunol. 52 (3): 240-8. Lim, J.H. et al., 2006, J Immunol. 177 (8): 5420-9.