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Cynomolgus IGFBP4 Protein (His Tag)
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Cynomolgus IGFBP4 Protein (His Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
90080-C08H  

YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Insulin-like growth factor binding protein 4 Protein Datasheet

 

IGFBP4 Protein Price Inquiry ( Available Sizes )

IGFBP4 Protein Product Information

Synonym : IGFBP4
Protein Construction:

A DNA sequence encoding the cynomolgus IGFBP4(Met1-Glu258 ) was expressed with a polyhistidine tag at the C-terminus.

Source: Cynomolgus
Expression Host: Human Cells

IGFBP4 Protein QC Testing

Purity: > 80 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

IGFBP4 protein

Bio-activity:

Measured by its ability to inhibit the biological activity of IGFI or IGFII on MCF7 human breast adenocarcinoma cells (Karey, K.P. et al. (1988) Cancer Research 48:4083.).
The ED50 for this effect is typically 0.04-0.2 μg/mL in the presence of 14 ng/mL human IGFII.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Asp 22
Molecular Mass:

The recombinant heterodimer of cynomolgus IGFBP4 comprises 248 amino acids and has a calculated molecular mass of 27.4 KDa. The apparent molecular mass of the protein is approximately 33-36 KDa respectively in SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

IGFBP4 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IGFBP4 Protein Related Products & Topics

Related Areas:

Cancer>>Growth Factor & Receptor>>IGF System>>IGFBP4

Proteins:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
IGFBP4 Human IGFBP4 Protein, Recombinant 10967-H08H
IGFBP4 Mouse IGFBP4 Protein, Recombinant 50250-M08H
IGFBP4 Cynomolgus IGFBP4 Protein, Recombinant 90080-C08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
IGFBP4
WB, ELISA Mouse Monoclonal Antibody 10967-MM02
Mouse
IGFBP4
WB, ELISA Rabbit Polyclonal Antibody 50250-RP02

IGFBP4 Protein Description

Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes. Six high-affinity IGF-binding proteins (IGFBP-1 to -6) have been identified, and IGFBP4, the smallest IGFBP expressed by a wide range of cell types, exists in both non-glycosylated and N-glycosylated forms in all biological fluids. Structurally consisting of an IGFBP domain and a thyroglobulin type-I domain, IGFBP4 binds IGF-I and IGF-II with similar affinities as a transport protein and modulates their biological effects. Increasing evidences indicate that IGFBP4 inhibits IGF-induced cellular growth both in vitro and in vivo. As an important member of the IGF system, IGFBP4 is involved in a wide range of biological processes including reproductive physiology, bone formation, renal pathophysiology and carcinomas.

References

  1. Durai R. et al., 2006, Int J Oncol. 28: 1317-25.
  2. Sitar T. et al., 2006, Proc Natl Acad Sci. 103: 13028-33.
  3. Zhou R. et al., 2003, J Endocrinol. 178: 177-93.
  4. Zhou J. et al., 2003, Biol Reprod. 69: 22-9.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"