IGFBP4 Protein & Antibody

Insulin-like Growth Factor Binding Protein 4

IGFBP4 Products

IGFBP4 Protein, Recombinant

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
IGFBP4	Human	IGFBP4 Protein, Recombinant	10967-H08H
IGFBP4	Mouse	IGFBP4 Protein, Recombinant	50250-M08H

  50250-M08H: The ED₅₀ for this effect is typically 5-10 µg/mL. Measured in a serumfree cell proliferation assay using MCF7 human breast adenocarcinoma cells.(Karey, K.P. et al. 1988, Cancer Research 48: 4083.).

IGFBP4 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IGFBP4	WB, ELISA	Mouse Monoclonal Antibody	10967-MM02
Mouse IGFBP4	WB, ELISA	Rabbit Polyclonal Antibody	50250-RP02

IGFBP4 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IGFBP4	Human	IGFBP4 cDNA Clone / ORF Clone	HG10967-M
IGFBP4	Mouse	IGFBP4 cDNA Clone / ORF Clone	MG50250-M
IGFBP4	Cynomolgus	IGFBP4 cDNA Clone / ORF Clone	KG90080-G

IGFBP4 Alternative Names

IGFBP4, IGFBP-4, BP-4, HT29-IGFBP, IBP4 [Homo sapiens]

Igfbp4, IGFBP-4, RP23-333D2.6, AI875747, Deb2 [Mus musculus]

IGFBP4 Related Areas

Cancer>>Growth Factor & Receptor>>IGF System>>IGFBP4

IGFBP4 Related Products

Protein Products

Molecule	Species	Description
CCN3/NOV/IGFBP9	Human	CCN3/NOV/IGFBP9 Protein, Recombinant
CCN4/WISP1	Human	CCN4/WISP1 Protein, Recombinant
IGF1R/CD221	Human	IGF1R/CD221 Protein, Recombinant
IGFBP3	Human	IGFBP3 Protein, Recombinant
IGFBP6	Human	IGFBP6 Protein, Recombinant
IGFBP6	Mouse	IGFBP6 Protein, Recombinant
Insulin Receptor/CD220	Human	Insulin Receptor/CD220 Protein, Recombinant
Insulin Receptor/CD220	Human	Insulin Receptor/CD220 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human CCN3/NOV/IGFBP9	WB, ELISA	CCN3/NOV/IGFBP9 Antibody, Mouse Mab
Human CCN3/NOV/IGFBP9	WB, ELISA	Rabbit Polyclonal Antibody
Human IGF1R/CD221	WB	Mouse Monoclonal Antibody
Human IGF1R/CD221	WB	Mouse Monoclonal Antibody
Human IGF1R/CD221	ELISA	Mouse Monoclonal Antibody
Human IGF1R/CD221	WB, ELISA	Rabbit Monoclonal Antibody
Human IGF1R/CD221	ELISA	Rabbit Polyclonal Antibody
Human IGF1R/CD221	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human IGFBP3	WB, ELISA	Mouse Monoclonal Antibody
Human Insulin Receptor/CD220	WB, ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description
CCN3/NOV/IGFBP9	Human	Homo sapiens CCN3/NOV/IGFBP9 cDNA Clone(NM_002514.3)
CCN3/NOV/IGFBP9	Mouse	Mus musculus CCN3/NOV/IGFBP9 cDNA Clone
CCN4/WISP1	Human	Homo sapiens CCN4/WISP1 cDNA Clone(NM_003882.2)
IGF1R /CD221	Human	Homo sapiens IGF1R /CD221 cDNA Clone(NM_000875.3)
IGFBP3	Human	Homo sapiens IGFBP3 cDNA Clone(NM_000598.4)
IGFBP5	Human	Homo sapiens IGFBP5 cDNA Clone(NM_000599.3)
IGFBP5	Mouse	Mus musculus IGFBP5 cDNA Clone
IGFBP6	Human	Human IGFBP6 cDNA Clone / ORF Clone
IGFBP6	Mouse	Mus musculus IGFBP6 cDNA Clone
CCN3/NOV/IGFBP9	Human	Homo sapiens CCN3/NOV/IGFBP9 cDNA Clone(NM_002514.3)
CCN3/NOV/IGFBP9	Mouse	Mus musculus CCN3/NOV/IGFBP9 cDNA Clone

IGFBP4 Background

Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. Expression of IGFBP-4 mRNA in nontransgenic littermates was maximal in liver and kidney. IGFBP-4 is a functional antagonist of IGF-I action on SMC. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.

IGFBP4 Related Studies

1. Wang J, et al. (1998) Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology. 139(5): 2605-14.
2. Chernausek SD, et al. (1995) Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4. J Biol Chem. 1995 May 12;270(19):11377-82.