Anti-IGFBP4 Antibody

Cat: 10967-MM02
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All IGFBP4 Reagents
Anti-IGFBP4 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-IGFBP4 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human IGFBP4
No cross-reactivity with Human IGFBP3 / IBP3 in ELISA
Recombinant Human IGFBP4 protein (Catalog#10967-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IGFBP4 (rh IGFBP4; Catalog#10967-H08H; NP_001543.2; Met 1-Glu 258). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #5F7D12H3
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IGFBP4 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IGFBP4 Antibody Alternative Names
Anti-BP-4 Antibody;Anti-HT29-IGFBP Antibody;Anti-IBP4 Antibody;Anti-IGFBP-4 Antibody
IGFBP4 Background Information

Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. Expression of IGFBP-4 mRNA in nontransgenic littermates was maximal in liver and kidney. IGFBP-4 is a functional antagonist of IGF-I action on SMC. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.

Full Name
insulin-like growth factor binding protein 4
  • Wang J, et al. (1998) Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology. 139(5): 2605-14.
  • Chernausek SD, et al. (1995) Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4. J Biol Chem. 1995 May 12;270(19):11377-82.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IGFBP4 Antibody Mouse Monoclonal ELISA 90080-MM01
    Anti-IGFBP4 Antibody Rabbit Polyclonal ELISA,IHC-P 90080-T24
    Anti-IGFBP4 Antibody Rabbit Polyclonal ELISA 50250-RP02
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