Anti-IGFBP4 Antibody

Cat: 10967-MM02
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All IGFBP4 Reagents
CRO Services
Product recommended

All IGFBP4 Reagents
Anti-IGFBP4 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-IGFBP4 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IGFBP4
No cross-reactivity with Human IGFBP3 / IBP3 in ELISA
Immunogen
Recombinant Human IGFBP4 protein (Catalog#10967-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IGFBP4 (rh IGFBP4; Catalog#10967-H08H; NP_001543.2; Met 1-Glu 258). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #5F7D12H3
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IGFBP4 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IGFBP4 Antibody Alternative Names
Anti-BP-4 Antibody;Anti-HT29-IGFBP Antibody;Anti-IBP4 Antibody;Anti-IGFBP-4 Antibody
IGFBP4 Background Information

Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. Expression of IGFBP-4 mRNA in nontransgenic littermates was maximal in liver and kidney. IGFBP-4 is a functional antagonist of IGF-I action on SMC. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.

Full Name
insulin-like growth factor binding protein 4
References
  • Wang J, et al. (1998) Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology. 139(5): 2605-14.
  • Chernausek SD, et al. (1995) Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4. J Biol Chem. 1995 May 12;270(19):11377-82.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IGFBP4 Antibody Mouse Monoclonal ELISA 90080-MM01
    Anti-IGFBP4 Antibody Rabbit Polyclonal ELISA,IHC-P 90080-T24
    Anti-IGFBP4 Antibody Rabbit Polyclonal ELISA 50250-RP02
    info info
    添加购物车成功! 添加购物车失败!