CD40 Protein & Antibody (TNFRSF5)

Cluster of Differentiation 40 (Tumor Necrosis Factor Receptor Superfamily Member 5)

CD40 Products

CD40 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD40/TNFRSF5	Human	CD40/TNFRSF5/ Fc Protein, Recombinant	10774-H03H
CD40/TNFRSF5	Human	CD40/TNFRSF5 Protein, Recombinant	10774-H08H
CD40/TNFRSF5	Mouse	CD40/TNFRSF5 Protein, Recombinant	50324-M03H
CD40/TNFRSF5	Rat	CD40 / TNFRSF5 Protein, Recombinant	80151-R02H
CD40/TNFRSF5	Rat	TNFRSF5 / CD40 Protein, Recombinant	80151-R08H
CD40/TNFRSF5	Cynomolgus	TNFRSF5 / CD40 Protein, Recombinant	90097-C02H
CD40/TNFRSF5	Cynomolgus	TNFRSF5 / CD40 Protein, Recombinant	90097-C08H

10774-H03H: Immobilized recombinant human CD40 at 2 µg/ml (100 µl/well) can bind biotinylated human CD40L with a linear range of 7.8-125 ng/ml. Measured by its binding ability in a functional ELISA.

10774-H08H: Immobilized recombinant human CD40 at 2 µg/ml (100 µl/well) can bind biotinylated human CD40L with a linear range of 15.6-500 ng/ml. Measured by its binding ability in a functional ELISA.

50324-M03H Measured by its ability to bind recombinant human CD40L in a functional ELISA.

CD40 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD40/TNFRSF5	WB, FCM	CD40 / TNFRSF5 Antibody ( FITC )	10774-MM03-F
Human CD40/TNFRSF5	WB, ELISA	Mouse Monoclonal Antibody	10774-MM05
Human CD40/TNFRSF5	WB, ELISA	CD40/TNFRSF5 Antibody, Rabbit MAb	10774-R004
Human CD40/TNFRSF5	WB, ELISA	Rabbit Polyclonal Antibody	10774-RP01
Human CD40/TNFRSF5	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10774-RP02

CD40 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD40/TNFRSF5	Human	CD40 / TNFRSF5 cDNA Clone / ORF Clone	HG10774-M
CD40/TNFRSF5	Rat	CD40/TNFRSF5 cDNA Clone / ORF Clone	RG80177-G
CD40/TNFRSF5	Cynomolgus	CD40 cDNA Clone / ORF Clone	CG90096-G

CD40 ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD40/TNFRSF5	ELISA	CD40/TNFRSF5 ELISA Kit	SEK10774

CD40 Alternative Names

CD40, TNFRSF5, Bp50, CDW40, MGC9013, p50 [Homo sapiens]

Cd40, Tnfrsf5, RP23-428M13.1, AI326936, Bp50, GP39, HIGM1, IGM, IMD3, T-BAM, TRAP, p50 [Mus musculus]

CD40 Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD40/TNFRSF5

Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD40/TNFRSF5

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> CD40/TNFRSF5

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>CD40/TNFRSF5

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>> CD40/TNFRSF5

CD40 Protein Related Products

**Protein Products**
Molecule	Species	Description //For Detailed Info. and Price------CLICK!
CD120a/TNFRI /TNFRSF1A	Human	CD120a/Fc Protein, Recombinant
CD120a/TNFRI /TNFRSF1A	Human	CD120a Protein, Recombinant
CD120b/TNFRII/TNFRSF1B	Human	CD120b Protein, Recombinant
CD120b/TNFRII/TNFRSF1B	Human	CD120b/Fc Protein, Recombinant
CD134/TNFRSF4	Human	OX40/CD134/Fc Protein, Recombinant
CD134/TNFRSF4	Human	OX40/CD134 Protein, Recombinant
CD95/APO-1/TNFRSF6	Human	CD95/APO-1/TNFRSF6/Fc Protein, Recombinant
CD95/APO-1/ TNFRSF6	Human	CD95/APO-1/TNFRSF6 Protein, Recombinant
CD95/APO-1/TNFRSF6	Mouse	CD95/APO-1/TNFRSF6 Protein, Recombinant
CD95/APO-1/TNFRSF6	Rat	CD95/APO-1/TNFRSF6 Protein, Recombinant
CD27/TNFRSF7	Human	CD27/TNFRSF7/Fc Protein, Recombinant
CD27/TNFRSF7	Mouse	CD27/TNFRSF7/Fc Protein, Recombinant
CD27/TNFRSF7	Mouse	CD27/TNFRSF7 Protein, Recombinant
CD30/TNFRSF8	Human	CD30/TNFRSF8/Fc Protein, Recombinant
CD30/TNFRSF8	Human	CD30 Protein, Recombinant
CD137/4-1BB/TNFRSF9	Human	4-1BB/TNFRSF9/Fc Protein, Recombinant
CD137/4-1BB/TNFRSF9	Human	CD137/4-1BB/TNFRSF9 Protein, Recombinant
CD137/4-1BB/TNFRSF9	Mouse	CD137/4-1BB/TNFRSF9 Protein, Recombinant
CD261/TRAILR1/TNFRSF10A	Human	TRAIL R1/TNFRSF10A/CD261/Fc Protein, Recombinant
CD261/TRAILR1/TNFRSF10A	Human	TRAIL R1/TNFRSF10A/CD261/Fc Protein, Recombinant
CD261/TRAILR1/TNFRSF10A	Human	TRAIL R1/TNFRSF10A/CD261 Protein, Recombinant
CD262/TRAILR2/TNFRSF10B	Human	TRAILR2/Fc Protein, Recombinant
CD262/TRAILR2/TNFRSF10B	Human	TRAILR2 Protein, Recombinant
CD262/TRAILR2/TNFRSF10B	Mouse	TRAILR2/Fc Protein, Recombinant
CD262/TRAILR2/TNFRSF10B	Mouse	TRAILR2 Protein, Recombinant
CD264/TRAILR4/TNFRSF10D	Human	TRAILR4/Fc Protein, Recombinant
CD264/TRAILR4/TNFRSF10D	Human	TRAILR4 Protein, Recombinant
CD27L/CD70/TNFSF7	Human	CD70/Fc Protein, Recombinant
CD30L/TNFSF8	Human	CD30L/TNFSF8/Fc Protein, Recombinant
CD137L/4-1BBL/TNFSF9	Mouse	4-1BB Ligand Protein, Recombinant
CD137L/4-1BBL/TNFSF9	Human	4-1BB/TNFRSF9/Fc Protein, Recombinant

**Antibody Products**
Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human CD120a/TNFRI /TNFRSF1A	WB, ELISA	Rabbit Monoclonal Antibody
Human CD120a/TNFRI /TNFRSF1A	WB, ELISA	Rabbit Polyclonal Antibody
Human CD120a/TNFRI /TNFRSF1A	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human CD134/TNFRSF4	WB, ELISA	OX40/CD134 Antibody, Rabbit PAb
Human CD134/TNFRSF4	WB, ELISA	OX40/CD134 Antibody, Rabbit PAb (Antigen Affinity Purified)
Human CD95/APO-1/TNFRSF6	WB, ELISA	CD95/APO-1/TNFRSF6 Antibody, Rabbit PAb
Human CD95/APO-1/TNFRSF6	WB, ELISA	CD95/APO-1/TNFRSF6 Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse CD95/APO-1/TNFRSF6	WB, ELISA	CD95/APO-1/TNFRSF6 Antibody, Rabbit PAb
Mouse CD95/APO-1/TNFRSF6	WB, ELISA	CD95/APO-1/TNFRSF6 Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse CD137L/4-1BBL/TNFSF9	WB, ELISA	Rabbit Monoclonal Antibody
Mouse CD137L/4-1BBL/TNFSF9	ELISA	Rabbit Polyclonal Antibody
Mouse CD137L/4-1BBL/TNFSF9	WB, ELISA	Rabbit Polyclonal Antibody
Human CD262/TRAIL R2/TNFRSF10B	WB, ELISA	Rabbit Polyclonal Antibody
Human CD262/TRAIL R2/TNFRSF10B	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse CD262/TRAIL R2/TNFRSF10B	WB, ELISA	TRAIL R2/TNFRSF10B/CD262 Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse CD137L/4-1BBL/TNFSF9	WB, ELISA	Rabbit Monoclonal Antibody
Mouse CD27	WB, ELISA	CD27 Antibody, Rabbit PAb
Mouse CD27	WB, ELISA	CD27 Antibody, Rabbit PAb (Antigen Affinity Purified)

**cDNA Clone Products**
Molecule	Species	Description //For Detailed Info. and Price------CLICK!
CD120a/TNFRI /TNFRSF1A	Human	Homo sapiens CD120a/TNFRI cDNA Clone(NM_001065.2)
CD18/TNFRSF3	Human	Homo sapiens TNFRSF3 cDNA Clone(NM_002342.1)
CD134/TNFRSF4	Human	Homo sapiens TNFRSF4 cDNA Clone(NM_003327.2)
CD40/TNFRSF5	Human	Homo sapiens CD40/TNFRSF5 cDNA Clone(NM_001250.4)
CD95/TNFRSF6	Human	Homo sapiens CD95/Fas transcript variant 1 cDNA Clone(NM_000043.3)
CD95/APO-1/TNFRSF6	Mouse	Mus musculus CD95/APO-1/TNFRSF6 cDNA Clone
CD95/APO-1/TNFRSF6	Rat	Rattus norvegicus CD95/APO-1/TNFRSF6 cDNA Clone
CD137/4-1BB/TNFSF9	Human	Homo sapiens 4-1BB/TNFRSF9 cDNA Clone(NM_001561.4)
CD261/TRAILR1/TNFRSF10A	Human	Homo sapiens TRAILR1 cDNA Clone(NM_003844.2)
CD262/TRAILR2/TNFRSF10B	Human	Homo sapiens TRAILR2 cDNA Clone(NM_003842.3)
CD262/TRAILR2/TNFRSF10B	Mouse	Mus musculus TRAILR2 cDNA Clone
CD263/TRAILR3/TNFRSF10C	Human	Homo sapiens TRAILR3 cDNA Clone(NM_003841.2)
CD264/TRAILR4/TNFRSF10D	Human	Homo sapiens TRAILR4 cDNA Clone(NM_003840.3)
CD266/TNFRSF12	Human	Homo sapiens TNFRSF12 cDNA Clone(NM_016639.2)
CD27/TNFRSF7	Mouse	Mus musculus CD27/TNFRSF7 cDNA Clone
CD30/TNFRSF8	Human	Homo sapiens CD30/TNFRSF8 cDNA Clone
CD40L/CD154/TNFSF5	Human	Homo sapiens CD40L/TNFSF5 cDNA Clone(NM_000074.2)
CD95L/FASL/CD178/TNFSF6	Human	Homo sapiens FasL/TNFSF6 cDNA Clone(NM_000639.1)
CD27L/CD70/TNFSF7	Human	Homo sapiens CD27L/TNFSF7 cDNA Clone(NM_001252.3)
CD30L/CD153/TNFSF8	Human	Homo sapiens CD30L/TNFSF8 cDNA Clone(NM_001244.2)
CD253/ TNFSF10/TRAIL	Human	Homo sapiens TNFSF10/TRAIL cDNA Clone(NM_003810.2)
CD256/TNFSF13	Human	Homo sapiens TNFSF13 cDNA Clone(NM_003808.3)
CD257/TNFSF13B/TNFSF20	Human	Homo sapiens BAFF/TNFSF13B cDNA Clone(NM_006573.3)
TNFSF13B/TNFSF20	Mouse	Mus musculus BLyS/TNFSF13B cDNA Clone
CD258/ TNFSF14	Human	Homo sapiens LIGHT/TNFSF14 transcript variant 1 cDNA Clone(NM_003807.2)

CD40 Background

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

CD40 Related Studies

van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2–17.
Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311–24.
Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

CD40 related areas, pathways, and other information

TNF Superfamily Ligands

EDA-A1 / Ectodysplasin-A1^*	TNFSF5 / CD40L / CD154	TNFSF11 / RANKL / OPGL
TNF-alpha / TNFSF2	TNFSF6 / CD95L / CD178^*	TNFSF12 / TWEAK^*
TNF-beta / TNFSF1 / Lymphotoxin alpha	TNFSF7 / CD70 / CD27L	TNFSF13 / CD256^*
TNFSF3 / TNFC / lymphotoxin beta^*	TNFSF8 / CD153 / CD30L	TNFSF13B / BlyS / CD257
TNFSF3L / PGLYRP1 / PGRP-S	TNFSF9 / 4-1BBL / CD137L	TNFSF14 / LIGHT / CD258
TNFSF4^*	TNFSF10 / CD253 / TRAIL	TNFSF15^*

TNF Receptor Superfamily

EDAR	TNFRSF9 / CD137 / 4-1BB	TNFRSF14 / HVEM
TNFRSF1A / TNFR1 / CD120a	TNFRSF10A / CD261 / TRAILR1	TNFRSF16 / NGFR / P75
TNFRSF1B / TNFR2 / CD120b	TNFRSF10B / CD262 / TRAILR2	TNFRSF17 / BCMA / CD269
TNFRSF3 / CD18 / LTBR^*	TNFRSF10C / CD263 / TRAILR3^*	TNFRSF18^*
TNFRSF4 / OX40 / CD134	TNFRSF10D / CD264 / TRAILR4	TNFRSF19 / TROY
TNFRSF5 / CD40	TNFRSF11A	TNFRSF19L / RELT
TNFRSF6 / CD95 / APO-1	TNFRSF11B / Osteoprotegerin	TNFRSF21 / DR6
TNFRSF6B / DcR3	TNFRSF12A / FN14 / TWEAKR^*	TNFRSF25 / DR3 / TNFRSF12
TNFRSF7 / CD27	TNFRSF13B / TACI	TNFRSF27 / XEDAR / EDA2R
TNFRSF8 / CD30	TNFRSF13C / BAFFR