Anti-IGFBP-3 Antibody

Cat: 10430-RP01
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Anti-IGFBP-3 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IGFBP-3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IGFBP-3
Immunogen
Recombinant Human IGFBP3 Protein (Catalog#10430-H07H)
Preparation
Produced in rabbits immunized with purified, recombinant Human IGFBP3 (rh IGFBP3; Catalog#10430-H07H; NP_000589.2; Gly 28-Lys 291). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IGFBP-3 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IGFBP-3 Antibody Alternative Names
Anti-BP-53 Antibody;Anti-IBP3 Antibody;Anti-IGFBP3 Antibody
IGFBP-3 Background Information

The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and has been shown to be a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism, where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signalling appears to require an active transforming growth factor beta (TGF-beta) signalling pathway, and IGFBP3 stimulates phosphorylation of the TGF-beta signalling intermediates Smad2 and Smad3. IGFBP3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor, retinoid X receptor (RXR)-alpha, and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer, prostate cancer, colorectal cancer, and lung cancer. Moreover, IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF.

Full Name
insulin-like growth factor binding protein 3
References
  • Baxter RC. (2001) Signalling pathways involved in antiproliferative effects of IGFBP-3: a review. Mol Pathol. 54(3): 145-8.
  • Butt AJ, et al. (2001) IGFBP-3 and apoptosis--a license to kill? Apoptosis. 6(3): 199-205.
  • Ali O, et al. (2003) Epidemiology and biology of insulin-like growth factor binding protein-3 (IGFBP-3) as an anti-cancer molecule. Horm Metab Res. 35(11-12): 726-33.
  • Yamada PM, et al. (2009) Perspectives in mammalian IGFBP-3 biology: local vs. systemic action. Am J Physiol Cell Physiol. 296(5): C954-76.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IGFBP-3 Antibody Rabbit Polyclonal ELISA,IHC-P 90084-T24
    Anti-IGFBP-3 Antibody Rabbit Polyclonal ELISA 90084-RP01
    Anti-IGFBP-3 Antibody Mouse Monoclonal ELISA 10430-MM01
    Anti-IGFBP-3 Antibody Rabbit Monoclonal ELISA,ELISA(Det) 10430-R008
    Anti-IGFBP-3 Antibody Rabbit Monoclonal ELISA(Cap) 10430-R010
    Anti-IGFBP-3 Antibody Rabbit Polyclonal ELISA 10430-T16
    Anti-IGFBP-3 Antibody Rabbit Polyclonal ELISA 10430-RP02
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