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IGF1R Protein & Antibody (IGFR, CD221)

Insulin-like Growth Factor-1 Receptor

IGF1R Protein & Antibody Products

IGF1R Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
IGF1R/CD221 Human IGF1R /CD221 Protein, Recombinant 10164-H08H
IGF1R/CD221 Human CD221 / IGF1R Protein, Recombinant, with GST Tag 10164-H20B1

  10164-H08H:  Measured by its ability to bind biotinylated human IGF1 in a functional ELISA.

IGF1R Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
IGF1R/CD221
WB Mouse Monoclonal Antibody 10164-MM02
Human
IGF1R/CD221
WB Mouse Monoclonal Antibody 10164-MM03
Human
IGF1R/CD221
ELISA Mouse Monoclonal Antibody 10164-MM04
Human
IGF1R/CD221
WB, ELISA Rabbit Monoclonal Antibody 10164-R011
Human
IGF1R/CD221
ELISA Rabbit Polyclonal Antibody 10164-RP01
Human
IGF1R/CD221
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 10164-RP02

IGF1R ELISA Kit

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human IGF1R/CD221 ELISA IGF1R/CD221 ELISA Kit SEK10164

IGF1R cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CD221/IGF1R Human Human CD221/IGF1R cDNA Clone / ORF Clone HG10164-M
CD221/IGF1R Mouse Mouse IGF1R cDNA Clone / ORF Clone MG51038-G
CD221/IGF1R Canine Canine IGF1R Gene cDNA Clone / ORF Clone DG70098-G
CD221/IGF1R Cynomolgus Cynomolgus monkey IGF1R cDNA Clone / ORF Clone CG90082-G

IGF1R Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>IGF1R/CD221

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>IGF1R/CD221

Cancer>>Cancer Biomarkers>>IGF1R/CD221

Cancer>>Growth Factor & Receptor>>IGF System>>IGF1R/CD221

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>IGF1R/CD221

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Adhesion>>IGF1R/CD221

IGF1R Alternative Names

IGF1R, IGFIR, CD221, JTK13, MGC142170, MGC142172, MGC18216 [Homo sapiens]

Igf1r, A330103N21Rik, CD221, D930020L01, IGF-1R, hyft [Mus musculus]

IGF1R Background

The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. IGF1R signalling pathway is activated in the mammalian nervous system from early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signalling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

IGF1R Related Studies

  1. Bähr C, et al. (2004) The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm IGF Res. 14 (4): 287-95.
  2. Riedemann J, et al. (2006) IGF1R signalling and its inhibition. Endocr Relat Cancer. 13 Suppl 1: 33-43.
  3. Gualco E, et al. (2009) IGF-IR in neuroprotection and brain tumors. Front Biosci. 14: 352-75.
  4. Annenkov A. (2009) The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis. Mol Neurobiol. 40 (3): 195-215.

IGF1R related areas, pathways, and other information

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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