Anti-IGF1R Antibody

Cat: 10164-RP02
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Anti-IGF1R Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IGF1R Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IGF1R
Immunogen
Recombinant Human IGF1R protein (Catalog#10164-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human IGF1 receptor / CD221 extracellular domain (rhIGF1R; Catalog#10164-H08H; Met 1-Asn 932; NP_000866.1). IGF1R specific IgG was purified by human IGF1R affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IGF1R Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IGF1R Antibody Alternative Names
Anti-CD221 Antibody;Anti-IGF-I R Antibody;Anti-IGF1 Receptor Antibody;Anti-IGFIR Antibody;Anti-IGFR Antibody;Anti-JTK13 Antibody
IGF1R Background Information

The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. IGF1R signalling pathway is activated in the mammalian nervous system from early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signalling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
insulin-like growth factor 1 receptor
References
  • Bhr C, et al. (2004) The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm IGF Res. 14 (4): 287-95.
  • Riedemann J, et al. (2006) IGF1R signalling and its inhibition. Endocr Relat Cancer. 13 Suppl 1: 33-43.
  • Gualco E, et al. (2009) IGF-IR in neuroprotection and brain tumors. Front Biosci. 14: 352-75.
  • Annenkov A. (2009) The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis. Mol Neurobiol. 40 (3): 195-215.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IGF1R Antibody Rabbit Polyclonal ELISA 10164-RP01
    Anti-IGF1R Antibody Rabbit Monoclonal ELISA 10164-R011
    Anti-IGF1R Antibody Rabbit Monoclonal FCM,ICC/IF,IF 10164-R012
    Anti-IGF1R Antibody Mouse Monoclonal ELISA(Cap) 10164-MM07
    Anti-IGF1R Antibody (FITC) Rabbit Monoclonal FCM 10164-R012-F
    Anti-IGF1R Antibody (PE) Rabbit Monoclonal FCM 10164-R012-P
    Anti-IGF1R Antibody (APC) Rabbit Monoclonal FCM 10164-R012-A
    Anti-IGF1R Antibody Mouse Monoclonal ELISA 10164-MM04
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