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IGF1R/CD221/IGF-I R Rabbit MAb

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    Human IGF1R Antibody Product Information
    Immunogen:Recombinant Human IGF1R protein (Catalog#10164-H08H)
    Clone ID:11
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human IGF1R / CD221 extracellular domain (rh IGF1R; Catalog#10164-H08H; Met 1-Asn 932; NP_000866.1) .
    Other IGF1R Antibody Products
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10164-R012-F-100
    10164-R012-F-50
    100 Tests 
    50 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10164-RP01-400
      10164-RP01-100
      10164-RP01-200
       
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10164-MM04-200
        10164-MM04-50
        10164-MM04-100
        200 µg 
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10164-RP02-50
          10164-RP02-100
          10164-RP02-200
          50 µg 
          100 µg 
          200 µg 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10164-R012-P-50
          10164-R012-P-100
          50 Tests 
          100 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10164-R012-A-100
          10164-R012-A-50
          100 Tests 
          50 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  IF  ICC/IF  
          • Slide 1
          • Slide 1
          10164-R012-100
          10164-R012-50
          100 µg 
          50 µg 
          Add to Cart
          IGF1R/CD221/IGF-I R Background

          The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. IGF1R signalling pathway is activated in the mammalian nervous system from early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signalling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

          Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

          Human IGF1R/CD221/IGF-I R References
        • Bhr C, et al. (2004) The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm IGF Res. 14 (4): 287-95.
        • Riedemann J, et al. (2006) IGF1R signalling and its inhibition. Endocr Relat Cancer. 13 Suppl 1: 33-43.
        • Gualco E, et al. (2009) IGF-IR in neuroprotection and brain tumors. Front Biosci. 14: 352-75.
        • Annenkov A. (2009) The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis. Mol Neurobiol. 40 (3): 195-215.
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          Size / Price
          Catalog: 10164-R011-100
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          Datasheet & Documentation

          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"