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IGF1R / CD221 Antibody, Rabbit PAb

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Human IGF1R Antibody Product Information
Immunogen:Recombinant Human IGF1R protein (Catalog#10164-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human IGF1 receptor / CD221 extracellular domain (rhIGF1R; Catalog#10164-H08H; Met 1-Asn 932; NP_000866.1). Total IgG was purified by Protein A affinity chromatography.
Human IGF1R Antibody Usage Guide
Specificity:Human IGF1R / CD221
Application:ELISA

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human IGF1R. The detection limit for Human IGF1R is approximately 1.25 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other IGF1R Antibody Products
Reactivity: Human  
Application: FCM  
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10164-R012-F-100
10164-R012-F-50
100 Tests 
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Reactivity: Human  
Application: ELISA  
    10164-MM04-200
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    Application: ELISA  
      10164-R011-50
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      Reactivity: Human  
      Application: ELISA  
        10164-RP02-50
        10164-RP02-100
        10164-RP02-200
        50 µg 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10164-R012-P-50
        10164-R012-P-100
        50 Tests 
        100 Tests 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10164-R012-A-100
        10164-R012-A-50
        100 Tests 
        50 Tests 
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        Reactivity: Human  
        Application: FCM  IF  ICC/IF  
        • Slide 1
        • Slide 1
        10164-R012-100
        10164-R012-50
        100 µg 
        50 µg 
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        IGF1R/CD221/IGF-I R Background

        The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. IGF1R signalling pathway is activated in the mammalian nervous system from early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signalling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

        Human IGF1R/CD221/IGF-I R References
      • Bhr C, et al. (2004) The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm IGF Res. 14 (4): 287-95.
      • Riedemann J, et al. (2006) IGF1R signalling and its inhibition. Endocr Relat Cancer. 13 Suppl 1: 33-43.
      • Gualco E, et al. (2009) IGF-IR in neuroprotection and brain tumors. Front Biosci. 14: 352-75.
      • Annenkov A. (2009) The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis. Mol Neurobiol. 40 (3): 195-215.
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        Catalog: 10164-RP01-400
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        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"