IFN-omega Protein, Human, Recombinant (His Tag)

Cat: 10353-H08H
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IFN-omega Protein, Human, Recombinant (His Tag) Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV).
The ED50 for this effect is typically 2-8 pg/mL.
Protein Construction
A DNA sequence encoding the human IFNW1 (P05000) (Met1-Ser195) was expressed with a polyhistidine tag at the C-terminus.
Reference#
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Leu 22
Molecule Mass
The recombinant human IFNW1 consists of 185 amino acids and predicts a molecular mass of 21.6 KDa. It migrates as an approximately 22 KDa band in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IFN-omega Protein, Human, Recombinant (His Tag) in SDS-PAGE
Human IFN omega Protein 8709
IFN-omega Protein, Human, Recombinant (His Tag) Alternative Names
IFN-omega 1 Protein, Human;IFNW1 Protein, Human;interferon omega-1 Protein, Human
IFN-omega Background Information

IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I  and type I I, on the basis of differences in receptor binding and nucleotide sequence. Type I IFNs consist of IFN α, β, τ, and ω and bind to the type I  IFN receptor, whereas IFN-γ is the only type I I IFN and is specific for the type I I IFN receptor. Human IFN-ω, was identified by three independent groups in 1985 and is structurally related to IFN-α and -β. Both human IFN-ω and IFN-α are produced by virally induced leukocytes and have similar antiviral activities on human cell lines, and a sizeable proportion (at least 10%) of the total antiviral activity of leukocyte IFN is contributed by IFN-ωl. In addition, it was reported that IFN-ω could inhibit the growth of human tumors in vivo.

Full Name
interferon, omega 1
References
  • Capon D.J., et al.,(1985), Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides. Mol. Cell. Biol. 5:768-779.
  • Adolf G.R., et al., (1991), Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein.Biochim. Biophys. Acta 1089:167-174.
  • Humphray S.J., et al.,(2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.
  • Other IFN-omega Proteins

    Human IFN-omega Proteins

    Product Name Cat.No.
    IFN-omega Protein, Human, Recombinant (Fc Tag) 10353-H01H
    info info
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