IFNGR2 Protein & Antibody

Interferon Gamma Receptor 2

IFNGR2 Products

IFNGR2 Protein, Recombinant

Molecule	Species	Description	Cat. No
IFNGR2	Mouse	IFNGR2 Protein, Recombinant	50665-M08H

  50665-M08H: The EC₅₀ for this effect is typically 0.8-4 µg/mL. Measured by its ability to inhibit rh IFNγ mediated protection of WISH human amnion cells infected with vesicular stomatitis virus (VSV) to viral lysis.

IFNGR2 Antibody

Molecule	Application	Description	Cat. No
Mouse IFNGR2	WB, ELISA	IFNGR2 Antibody (Antigen Affinity Purified)	50665-RP02

IFNGR2 cDNA Clone

Molecule	Species	Description	Cat. No
IFNGR2	Mouse	IFNGR2 cDNA Clone / ORF Clone	MG50665-M

IFNGR2 Related Areas

Immunology>>Adaptive Immunity >>B Cell>>IFNGR2

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IFNGR2

IFNGR2 Alternative Names

IFNGR2, AF-1, IFGR2, IFNGT1 [Homo sapiens]

Ifngr2, Ifgr2, Ifgt [Mus musculus]

IFNGR2 Background

Interferon gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. IFNGR2 is a component of the IFNgamma receptor complex along with the IFNgammaR alpha chain (IFNGR1), and is a new Bax suppressor. The C-terminal fragment (cytoplasmic domain) of IFNgammaR2 is expressed in human cancer cell lines of megakaryocytic cancer (DAMI), breast cancer (MDA-MD-468), and prostate cancer (PC3 cells). The Th1 cytokine IFNgamma, acting through its heterodimeric receptors, IFNgammaR1 and IFNgammaR2, in the induction/proliferation of Th1 cells, might suppress the Th2 responses that may underlie atopic asthma. IFNGR2 has always been seen as a key mechanism for shielding T lymphocytes from the antiproliferative effects of the IFNgamma-signal transducer and activator of transcription 1 (STAT1) pathway.

IFNGR2 Related Studies

1. Gao PS, et al. (1999). Nonpathogenic common variants of IFNGR1 and IFNGR2 in association with total serum IgE levels. Biochem Biophys Res Commun. 263(2): 425-9.
2. Regis G, et al. (2006). IFNgammaR2 trafficking tunes IFNgamma-STAT1 signaling in T lymphocytes. Trends Immunol. 27(2):96-101.
3. Al-Muhsen S, et al. (2008). The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases. J Allergy Clin Immunol. 122 (6): 1043-51.
4. Gomez JA, et al. (2009). The C-terminus of interferon gamma receptor beta chain (IFNgammaR2) has antiapoptotic activity as a Bax inhibitor. Cancer Biol Ther. 8(18): 1771-86.