IFNAR1 Protein & Antibody

Interferon (alpha, beta and omega) receptor 1

IFNAR1 Products

IFNAR1 Protein, Recombinant

Molecule	Species	Description	Cat. No
IFNAR1	Mouse	IFNAR1 Protein, Recombinant	50469-M08H
IFNAR1	Human	IFNAR1 / IFNAR Protein, Recombinant	13222-H02H
IFNAR1	Human	IFNAR1 Protein, Recombinant	13222-H08H

  50469-M08H: The EC₅₀ for this effect is typically 4-20 µg/mL. Measured by its ability to inhibit rh IFNβ mediated protection of WISH human amnion cells infected with vesicular stomatitis virus (VSV) to viral lysis.

IFNAR1 Antibody

Molecule	Application	Description	Cat. No
Mouse IFNAR1	WB, ELISA	IFNAR1 Antibody, Rabbit PAb	50469-RP01
Mouse IFNAR1	WB, ELISA	IFNAR1 Antibody, Rabbit PAb (Antigen Affinity Purified)	50469-RP02
Mouse IFNAR1	WB, ELISA	IFNAR1 Antibody, Rabbit MAb	50469-R114

IFNAR1 cDNA Clone

Molecule	Species	Description	Cat. No
IFNAR1	Mouse	IFNAR1 cDNA Clone / ORF Clone	MG50469-M
IFNAR1	Rat	IFNAR1 cDNA Clone / ORF Clone	RG80180-G
IFNAR1	Cynomolgus	Cynomolgus monkey IFNAR1 cDNA Clone / ORF Clone	KG90113-G

IFNAR1 Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IFNAR1

IFNAR1 Alternative Names

IFNAR1, IFNAR, IFN-R-1, IFRC, AVP, IFN-alpha-REC, IFNBR, CRF2-1 [Homo sapiens]

IFNAR1, IFNAR, IFN-R-1, IFRC, AVP, IFN-alpha-REC, IFNBR, CRF2-1 [Mus musculus]

Interferon (alpha, beta and omega) receptor 1

IFNAR1 Products

IFNAR1 Protein, Recombinant

Molecule	Species	Description	Cat. No
IFNAR1	Mouse	IFNAR1 Protein, Recombinant	50469-M08H
IFNAR1	Human	IFNAR1 / IFNAR Protein, Recombinant	13222-H02H
IFNAR1	Human	IFNAR1 Protein, Recombinant	13222-H08H

  50469-M08H: The EC₅₀ for this effect is typically 4-20 µg/mL. Measured by its ability to inhibit rh IFNβ mediated protection of WISH human amnion cells infected with vesicular stomatitis virus (VSV) to viral lysis.

IFNAR1 Antibody

Molecule	Application	Description	Cat. No
Mouse IFNAR1	WB, ELISA	IFNAR1 Antibody, Rabbit PAb	50469-RP01
Mouse IFNAR1	WB, ELISA	IFNAR1 Antibody, Rabbit PAb (Antigen Affinity Purified)	50469-RP02
Mouse IFNAR1	WB, ELISA	IFNAR1 Antibody, Rabbit MAb	50469-R114

IFNAR1 cDNA Clone

Molecule	Species	Description	Cat. No
IFNAR1	Mouse	IFNAR1 cDNA Clone / ORF Clone	MG50469-M
IFNAR1	Rat	IFNAR1 cDNA Clone / ORF Clone	RG80180-G
IFNAR1	Cynomolgus	Cynomolgus monkey IFNAR1 cDNA Clone / ORF Clone	KG90113-G

IFNAR1 Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IFNAR1

IFNAR1 Alternative Names

IFNAR1, IFNAR, IFN-R-1, IFRC, AVP, IFN-alpha-REC, IFNBR, CRF2-1 [Homo sapiens]

IFNAR1, IFNAR, IFN-R-1, IFRC, AVP, IFN-alpha-REC, IFNBR, CRF2-1 [Mus musculus]

Interferon (alpha, beta and omega) receptor 1

IFNAR1 Products

IFNAR1 Protein, Recombinant

Molecule	Species	Description	Cat. No
IFNAR1	Mouse	IFNAR1 Protein, Recombinant	50469-M08H
IFNAR1	Human	IFNAR1 / IFNAR Protein, Recombinant	13222-H02H
IFNAR1	Human	IFNAR1 Protein, Recombinant	13222-H08H

  50469-M08H: The EC₅₀ for this effect is typically 4-20 µg/mL. Measured by its ability to inhibit rh IFNβ mediated protection of WISH human amnion cells infected with vesicular stomatitis virus (VSV) to viral lysis.

IFNAR1 Antibody

Molecule	Application	Description	Cat. No
Mouse IFNAR1	WB, ELISA	IFNAR1 Antibody, Rabbit PAb	50469-RP01
Mouse IFNAR1	WB, ELISA	IFNAR1 Antibody, Rabbit PAb (Antigen Affinity Purified)	50469-RP02
Mouse IFNAR1	WB, ELISA	IFNAR1 Antibody, Rabbit MAb	50469-R114

IFNAR1 cDNA Clone

Molecule	Species	Description	Cat. No
IFNAR1	Mouse	IFNAR1 cDNA Clone / ORF Clone	MG50469-M
IFNAR1	Rat	IFNAR1 cDNA Clone / ORF Clone	RG80180-G
IFNAR1	Cynomolgus	Cynomolgus monkey IFNAR1 cDNA Clone / ORF Clone	KG90113-G

IFNAR1 Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IFNAR1

IFNAR1 Alternative Names

IFNAR1, IFNAR, IFN-R-1, IFRC, AVP, IFN-alpha-REC, IFNBR, CRF2-1 [Homo sapiens]

IFNAR1, IFNAR, IFN-R-1, IFRC, AVP, IFN-alpha-REC, IFNBR, CRF2-1 [Mus musculus]

IFNAR1 Background

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

IFNAR1 Related Studies

1. Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
2. Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
3. Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.