Anti-IFNAR1 Antibody

Cat: 50469-RP02
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All IFNAR1 Reagents
Anti-IFNAR1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IFNAR1 Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse IFNAR1
Immunogen
Recombinant Mouse IFNAR-1 protein (Catalog#50469-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse IFNAR-1 / CRF2-1 (rM IFNAR-1; Catalog#50469-M08H; NP_034638.2; Met 1-Thr 429). IFNAR-1 specific IgG was purified by mouse IFNAR-1 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IFNAR1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IFNAR1 Antibody (Rabbit Polyclonal antibody) Images
Mouse IFNAR1 Western blot (WB) 17401

Anti-IFNAR1 rabbit polyclonal antibody at 1:500 dilution

Lane A: Hela Membrane Lysate

Lysates/proteins at 20 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:63 kDa

Observed band size:63 kDa

(We are unsure as to the identity of these extra bands.)

Anti-IFNAR1 Antibody Alternative Names
Anti-CD118 Antibody;Anti-Ifar Antibody;Anti-Ifnar Antibody;Anti-Ifrc Antibody;Anti-Infar Antibody
IFNAR1 Background Information

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

Full Name
interferon (alpha, beta and omega) receptor 1
References
  • Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
  • Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
  • Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IFNAR1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P 90113-T48
    Anti-IFNAR1 Antibody Rabbit Monoclonal ELISA 50469-R114
    Anti-IFNAR1 Antibody Rabbit Monoclonal ELISA(Cap) 50469-R120
    Anti-IFNAR1 Antibody Rabbit Polyclonal WB,ELISA 50469-RP01
    Anti-IFNAR1 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 50469-R110
    Anti-IFNAR1 Antibody (PE) Rabbit Monoclonal FCM 50469-R110-P
    Anti-IFNAR1 Antibody (FITC) Rabbit Monoclonal FCM 50469-R110-F
    Anti-IFNAR1 Antibody Mouse Monoclonal ELISA(Det) 13222-MM05
    Anti-IFNAR1 Antibody Rabbit Polyclonal ELISA 13222-T16
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