IFNA5 Protein (IFN alpha 5 Protein)

Interferon alpha 5

IFNA5 Products

IFNA5 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IFNA5/IFN alpha 5	Human	IFNA5/IFN alpha 5/Fc Protein, Recombinant	10342-H01H
IFNA5/IFN alpha 5	Human	IFNA5 / IFNaG Protein, Recombinant	10342-H08H
IFNA5/IFN alpha 5	Rat	IFNA5 / IFNaG Protein，Recombinant	80205-R08H

  10342-H01H: The EC₅₀ for this effect is 0.25 ng/mL. Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV).

IFNA5 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IFNA5/IFN alpha 5	Human	Homo sapiens IFNA5/IFN alpha 5 cDNA Clone(NM_002169.1)	HG10342-M
IFNA5/IFN alpha 5	Rat	Rat IFNA5/IFN alpha 5 cDNA Clone	RG80205-G

IFNA5 Alternative Names

IFNA5, RP11-380P16.5 [Homo sapiens]

Ifna5, RP23-139P14.29, Ifa5 [Mus musculus]

IFNA5 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IFNA5/IFN alpha 5

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IFNA5/IFN alpha 5

IFNA5 Background

Interferon, alpha 5 (IFNA5) belongs to the alpha/beta interferon family. IFNA5 is the only IFNA subtype detected in normal liver, while a mixture of subtypes is observed in the liver tissue of patients with chronic hepatitis C. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.

IFNA5 Related Studies

1. Lau JY, et al. (1993) Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet. 342(8881): 1208-9.
2. Kessler DS, et al. (1990) Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 4(10): 1753-65.
3. Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A. 91(4): 1198-205.

Interferons

• IFNA1 / Interferon alpha 1
• IFNA10 / Interferon alpha 10
• IFNL1 / Interferon lambda 1 / IL-29
• IFNA2 / Interferon alpha 2
• IFNA13 / Interferon alpha 13
• IFNL3 / Interferon lambda 3 / IL-28B
• IFNA4 / Interferon alpha 4B
• IFNA14 / Interferon alpha 14
• IFNW / Interferon omega
• IFNA5 / Interferon alpha 5
• IFNB / Interferon beta
• IFNZ / Interferon zata
• IFNA7 / Interferon alpha 7
• IFNE / Interferon epsilon
• IFNA8 / Interferon alpha 8
• IFNG / Interferon gamma

Interferon Receptors

• IFNAR1 / Interferon alpha R1
• IFNGR1 / CD119 / Interferon gamma R1
• IFNGR2 / Interferon gamma R2
• IFNAR2 / Interferon alpha R2