Anti-interferon-alpha Antibody

Cat: 10342-RP01
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Anti-interferon-alpha Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-interferon-alpha Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human interferon-alpha
Immunogen
Recombinant Human IFNA5 / IFNaG protein (Catalog#10342-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human IFNA5 / IFNaG (rh IFNA5 / IFNaG; Catalog#10342-H08H; P01569; Met1-Glu189). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-interferon-alpha Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-interferon-alpha Antibody Alternative Names
Anti-IFN-alpha Antibody;Anti-IFN-alpha-5 Antibody;Anti-IFN-alphaG Antibody;Anti-INA5 Antibody;Anti-INFA5 Antibody;Anti-leIF G Antibody;Anti-RP11-380P16.5 Antibody
interferon-alpha Background Information

Interferon, alpha 5 (IFNA5) belongs to the alpha/beta interferon family. IFNA5 is the only IFNA subtype detected in normal liver, while a mixture of subtypes is observed in the liver tissue of patients with chronic hepatitis C. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.

Full Name
interferon, alpha 5
References
  • Lau JY, et al. (1993) Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet. 342(8881): 1208-9.
  • Kessler DS, et al. (1990) Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 4(10): 1753-65.
  • Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A. 91(4): 1198-205.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-interferon-alpha Antibody Rabbit Polyclonal ELISA 80205-RP01
    Anti-interferon-alpha Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 80205-T60
    Anti-interferon-alpha Antibody Rabbit Monoclonal ELISA 80205-R003
    Anti-interferon-alpha Antibody Rabbit Polyclonal ELISA 51126-RP01
    Anti-interferon-alpha Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 51126-T60
    Anti-interferon-alpha Antibody Rabbit Monoclonal ELISA(Cap) 10342-R102
    Anti-interferon-alpha Antibody Rabbit Monoclonal ELISA 10342-R126
    Anti-interferon-alpha Antibody Rabbit Polyclonal ELISA 10342-T16
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