IFNA4 Protein (IFN alpha 4 Protein)

Interferon alpha 4

IFNA4 Products

IFNA4 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IFNA4	Human	IFNA4/IFN alpha 4A/Fc Protein, Recombinant	10336-H01H
IFNA4	Mouse	IFNA4 Protein, Recombinant	50672-M01H
IFNA4	Human	IFNα4 / IFNa4 / Interferon alpha-4 Protein, Recombinant	10336-H08B

  10336-H01H: The EC₅₀ for this effect is 0.92 ng/mL. Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV).

IFNA4 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IFNA4	Human	Homo sapiens IFNA4/IFN alpha 4A cDNA Clone(NM_021068.2)	HG10336-M
IFNA4	Mouse	Mouse IFNA4/IFN alpha 4 cDNA Clone / ORF Clone	MG50672-M
IFNA4	Rat	IFNA4 cDNA Clone / ORF Clone	RG80173-G

IFNA4 Alternative Names

IFNA4, MGC142200 [Homo sapiens]

Ifna4, Ifa4, RP23-139P14.30, MGC143607 [Mus musculus]

IFNA4 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IFNA4

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IFNA4

IFNA4 Background

Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 and 410 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.

IFNA4 Related Studies

1. Lau JY, et al. (1993) Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet. 342(8881): 1208-9.
2. Kessler DS, et al. (1990) Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 4(10): 1753-65.
3. Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A. 91(4): 1198-205.