Interferon, alpha 14
IFNA14 Protein, Recombinant
IFNA14 Cell Lysates
IFNA14 cDNA Clone
IFNA14 Related Areas
Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IFNA14
IFNA14 Alternative Names
IFNA14, IFN-alphaH, LEIF2H, MGC125756, MGC125757 [Homo sapiens]
Ifna14, RP23-67C1.2, MGC155959, OTTMUSG00000007662 [Mus musculus]
Interferon, alpha 14 (IFNA14) belongs to the alpha/beta interferon family. Interferons are produced by macrophages, IFN alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation. IFN alpha is substantially superior to conventional chemotherapy in terms of quality-adjusted survival.
IFNA14 Related Studies
- Lau JY, et al. (1993) Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet. 342(8881): 1208-9.
- Kessler DS, et al. (1990) Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 4(10): 1753-65.
- Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A. 91(4): 1198-205.