Anti-Interferon Gamma Antibody

Cat: 11725-RP02
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Anti-Interferon Gamma Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Interferon Gamma Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Interferon Gamma
Immunogen
Recombinant Human IFNG protein (Catalog#11725-HNAS)
Preparation
Produced in rabbits immunized with purified, recombinant Human IFNG (rh IFNG; Catalog#11725-HNAS; NP_000610.2; Met 1-Gln 166). IFNG IgG was purified by human IFNG affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Interferon Gamma Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Interferon Gamma Antibody Alternative Names
Anti-IFG Antibody;Anti-IFI Antibody;Anti-IFN gamma Antibody;Anti-Interferon Gamma Antibody
Interferon Gamma Background Information

IFN gamma, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interferon, gamma
References
  • Gray P W, et al. (1982) Structure of the human immune interferon gene. Nature. 298: 859-63.
  • Taya Y, et al. (1982) Cloning and structure of the human immune interferon-gamma chromosomal gene. EMBO J. 1: 953-8.
  • Goshima N, et al. (2008) Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nomura N Nat Methods. 5: 1011-7.
  • Thiel DJ, et al. (2000) Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. 8 (9): 927-36.
  • Naylor SL, et al. (1983) Human immune interferon gene is located on chromosome 12. J Exp Med. 157 (3): 1020-7.
  • Schoenborn JR, et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol. 96: 41-101.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Interferon Gamma Antibody Rabbit Polyclonal ELISA 90008-RP01
    Anti-Interferon Gamma Antibody Rabbit Polyclonal ELISA 90008-T16
    Anti-Interferon Gamma Antibody Rabbit Polyclonal ELISA 50709-T16
    Anti-Interferon Gamma Antibody Rabbit Monoclonal ELISA 50709-R002
    Anti-Interferon Gamma Antibody Rabbit Polyclonal IHC-P 105995-T08
    Anti-Interferon Gamma Antibody Rabbit Monoclonal FCM 11725-R003
    Anti-Interferon Gamma Antibody (APC) Rabbit Monoclonal FCM 11725-R003-A
    Anti-Interferon Gamma Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 11725-R121
    Anti-Interferon Gamma Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 11725-R238
    Anti-Interferon Gamma Antibody Rabbit Polyclonal ELISA 11725-RP01
    Anti-Interferon Gamma Antibody Mouse Monoclonal WB 11725-M005
    Anti-Interferon Gamma Antibody (PE) Rabbit Monoclonal FCM 11725-R003-P
    Anti-Interferon Gamma Antibody (FITC) Rabbit Monoclonal FCM 11725-R003-F
    Anti-Interferon Gamma Antibody Rabbit Polyclonal IHC-P 105908-T08
    Anti-Interferon Gamma Antibody Rabbit Monoclonal ELISA,ELISA(Det) 11725-R209
    Anti-Interferon Gamma Antibody (PerCP) Rabbit Monoclonal FCM 11725-R003-C
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