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Interferon Gamma/IFN gamma/IFNG Rabbit PAb

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    Human IFNG Antibody Product Information
    Immunogen:Recombinant Human IFNG protein (Catalog#11725-HNAS)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human IFNG (rh IFNG; Catalog#11725-HNAS; NP_000610.2; Met 1-Gln 166). Total IgG was purified by Protein A affinity chromatography.
    Other IFNG Antibody Products
    Reactivity: Human  
    Application: ELISA  
      11725-RP02-50
      11725-RP02-100
      11725-RP02-200
      50 µg 
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        11725-R121-50
        11725-R121-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        11725-R003-F-100
        11725-R003-F-50
        100 Tests 
        50 Tests 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        11725-R003-P-100
        11725-R003-P-50
        100 Tests 
        50 Tests 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        11725-R003-100
        11725-R003-50
        100 µg 
        50 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50709-RP01-400
          50709-RP01-100
          50709-RP01-200
           
          100 µg 
          200 µg 
          Add to Cart
          Reactivity: Cynomolgus  
          Application: ELISA  
            90008-T16-100
            90008-T16-50
            90008-T16-200
            100 µg 
            50 µg 
            200 µg 
            Add to Cart
            Reactivity: Rhesus  
            Application: ELISA  
              90008-RP01-400
              90008-RP01-200
              90008-RP01-100
               
              200 µg 
              100 µg 
              Add to Cart
              Interferon Gamma/IFN gamma/IFNG Background

              IFN gamma, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.

              Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

              Human Interferon Gamma/IFN gamma/IFNG References
            • Gray P W, et al. (1982) Structure of the human immune interferon gene. Nature. 298: 859-63.
            • Taya Y, et al. (1982) Cloning and structure of the human immune interferon-gamma chromosomal gene. EMBO J. 1: 953-8.
            • Goshima N, et al. (2008) Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nomura N Nat Methods. 5: 1011-7.
            • Thiel DJ, et al. (2000) Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. 8 (9): 927-36.
            • Naylor SL, et al. (1983) Human immune interferon gene is located on chromosome 12. J Exp Med. 157 (3): 1020-7.
            • Schoenborn JR, et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol. 96: 41-101.
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              Catalog: 11725-RP01-100
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              Datasheet & Documentation

              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"