IDO2 Protein

Indoleamine 2,3-dioxygenase 2

IDO2 Products

IDO2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
IDO2	Human	IDO2 Protein, Recombinant	13614-H08E

IDO2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
IDO2	Human	Human IDO2 cDNA Clone / ORF Clone	HG13614-G

IDO2 Related Areas

Enzyme>>Other>> IDO2

IDO2 Alternative Names

INDOL1, IDO-2, indoleamine 2,3-dioxygenase-like 1 protein, indoleamine 2,3-dioxygenase-like protein 1, indoleamine-pyrrole 2,3 dioxygenase-like 1, indoleamine-pyrrole 2,3-dioxygenase-like protein 1 [Homo sapiens]

C230043N17, AI265623, C230043N17Rik, Ido-2, Indol1, indoleamine 2,3-dioxygenase-like protein 1, indoleamine-pyrrole 2,3 dioxygenase-like 1 [Mus musculus]

IDO2 Background

IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of tryptophan and other indole derivatives to kynurenines. In addition to classic IDO (IDO1), a new variant, IDO2, has recently been described. IDO2 is expressed in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. IDO is widely distributed in human tissues, its physiological role is not fully understood but is of great interest. IDO can be up-regulated via cytokines such as interferon-gamma, and can thereby modulate the levels of tryptophan, which is vital for cell growth. In humans and mice, the IDO1 and IDO2 genes are present tandemly in a tail-to-head arrangment on chromosome 8. In lower vertebrates such as zebrafish and toads only a single IDO gene may be present that may be more IDO2-like in structure. This closer relationship to IDO2 suggests that IDO2 may actually be the ancestor of the better characterized IDO1 gene, and that IDO1 might have been generated by gene duplication of IDO2 before the origin of tetrapods in mammalian evolutionary history. IDO2 catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.

IDO2 Related Studies

1. Witkiewicz AK, et al. (2009) Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. J Am Coll Surg. 208 (5): 781-7.
2. Sorensen RB, et al. (2011) Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2. Cancer Res. 71 (6): 2038-44.
3. Witkiewicz AK, et al. (2009) Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. J Am Coll Surg. 208 (5): 781-7.