IDH1 Protein

Isocitrate dehydrogenase 1 (NADP+), soluble

IDH1 Products

IDH1 Protein, Recombinant

Molecule	Species	Description	Cat. No
IDH1	Human	IDH1 Protein, Recombinant	12055-H08E

IDH1 cDNA Clone

Molecule	Species	Description	Cat. No
IDH1	Human	Human IDH1 cDNA Clone / ORF Clone	HG12055-G

IDH1 Related Areas

Enzyme>>Other>>IDH1

IDH1 Alternative Names

IDH1, IDCD, IDH, IDP, IDPC, PICD [Homo sapiens]

Idh1, AI314845, AI788952, E030024J03Rik, Id-1, Idh-1, Idpc, MGC115782 [Mus musculus]

IDH1 Background

IDH1, or Isocitrate dehydrogenases 1, is highly expressed in the mammalian liver and moderately expressed in other tissues. IDH1localizes to varying extents to the cytoplasm and peroxisome of yeast and mammalian cells. The NADP(+)-dependent isocitrate dehydrogenases 1 (IDH1) functions at a crossroads of cellular metabolism in lipid synthesis, cellular defense against oxidative stress, oxidative respiration, and oxygen-sensing signal transduction. IDH1 mutations are usually heterozygous in cancer, and they appear to confer a neomorphic enzyme activity for the enzymes to catalyze the production of D-2-hydroxyglutarate. IDH1 mutations have recently been identified as early and frequent genetic alterations in astrocytomas, oligodendrogliomas, and oligoastrocytomas, as well as secondary glioblastomas, whereas primary glioblastomas very rarely contain IDH1 mutations.

IDH1 Related Studies

1. Takano S, et al. (2011) Detection of IDH1 mutation in human gliomas: comparison of immunohistochemistry and sequencing. Brain Tumor Pathol. 28(2): 115-23.
2. Geisbrecht BV, et al. (1999) The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. J Biol Chem. 274(43): 30527-30533.
3. Nekrutenko A, et al. (1998) Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family. Mol Biol Evol. 15(12): 1674-1684.
4. Henke B, et al. (1998) IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acids. J Biol Chem. 273(6): 3702-3711.
5. Gabriel JL, et al. (1986) Activity of purified NAD-specific isocitrate dehydrogenase at modulator and substrate concentrations approximating conditions in mitochondria. Metabolism. 35(7): 661-667.