ICOS Ligand / B7-H2 Protein & Antibody

ICOS Ligand / B7-H2 Products

ICOS Ligand / B7-H2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ICOS Ligand/B7-H2	Human	ICOS Ligand/B7-H2 Protein, Recombinant	11559-H08H
ICOS Ligand/B7-H2	Mouse	ICOS Ligand/B7-H2/Fc Protein, Recombinant	50190-M03H
ICOS Ligand/B7-H2	Mouse	ICOS Ligand/B7-H2 Protein, Recombinant	50190-M08H

  11559-H08H:  Immobilized human B7-H2 at 1 µg/ml (100 µl/well) can bind human ICOS with a linear range of 1.6-200 ng/ml. Measured by its binding ability in a functional ELISA.

  50190-M03H:  Immobilized human ICOS at 1 µg/ml (100 µl/well) can bind biotinylated mouse B7-H2 Fc chimera with a linear range of 0.125-1.0 µg/ml. Measured by its binding ability in a functional ELISA.

  50190-M08H:  Immobilized mouse B7-H2 at 1 µg/ml (100 µl/well) can bind human ICOS with a linear range of 40-1000 ng/ml. Measured by its binding ability in a functional ELISA.

ICOS Ligand / B7-H2 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human ICOS Ligand/B7-H2	WB, ELISA	ICOS Ligand/B7-H2 Antibody, Rabbit PAb	11559-RP01
Human ICOS Ligand/B7-H2	WB, ELISA	ICOS Ligand/B7-H2 Antibody, Rabbit PAb (Antigen Affinity Purified)	11559-RP02
Human ICOS Ligand/B7-H2	WB	ICOS Ligand / B7-H2 / ICOSLG Antibody	11559-MM03
Human ICOS Ligand/B7-H2	ELISA	ICOS Ligand / B7-H2 / ICOSLG Antibody	11559-MM07
Mouse ICOS Ligand/B7-H2	WB, ELISA	Rabbit Polyclonal Antibody	50190-RP01
Mouse ICOS Ligand/B7-H2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50190-RP02

ICOS Ligand / B7-H2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ICOS Ligand/B7-H2	Human	Homo sapiens ICOS Ligand/B7-H2 cDNA Clone	HG11559-M
ICOS Ligand/B7-H2	Mouse	Mus musculus ICOS Ligand/B7-H2 cDNA Clone	MG50190-M

ICOS Ligand / B7-H2 Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>ICOS Ligand/B7-H2

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>ICOS Ligand/B7-H2/CD275

ICOS Ligand / B7-H2 Alternative Names

ICOS Ligand, B7-H2, B7H2, ICOSLG, ICOS-L, ICOSL, B7RP-1, B7RP1, CD275, GL50, KIAA0653, LICOS [Homo sapiens]

ICOS Ligand, B7-H2, Icosl, Icoslg, ICOS-L, B7RP-1, B7h, GI50, GL50, GL50-B, KIAA0653, Ly115l, BG071784, AU044799, mKIAA0653, LICOS [Mus musculus]

ICOS Ligand / B7-H2 Background

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

ICOS Ligand / B7-H2 Related Studies

1. Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
2. Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
3. Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.