Quick Order

ICOSL/ICOS ligand/B7-h2 Mouse MAb

    DatasheetReviewsRelated ProductsProtocols
    Human B7-H2/ICOSLG Antibody Product Information
    Immunogen:Recombinant Human ICOS Ligand / B7-H2 / ICOSLG protein (Catalog#11559-H08H)
    Clone ID:4H2B1
    Ig Type:Mouse IgG1
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICOS Ligand / B7-H2 / ICOSLG (rh ICOS Ligand / B7-H2 / ICOSLG; Catalog#11559-H08H; NP_056074.1; Met 1-Ser 258). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other B7-H2/ICOSLG Antibody Products
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    11559-MM01-F-100
    11559-MM01-F-50
    100 Tests 
    50 Tests 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    11559-MM01-P-100
    11559-MM01-P-50
    100 Tests 
    50 Tests 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    11559-MM01-A-100
    11559-MM01-A-50
    100 Tests 
    50 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      11559-RP01-400
      11559-RP01-100
      11559-RP01-200
       
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        11559-RP02-200
        11559-RP02-50
        11559-RP02-100
        200 µg 
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        11559-R101-F-50
        11559-R101-F-100
        50 Tests 
        100 Tests 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        11559-MM01-50
        11559-MM01-200
        11559-MM01-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50190-RP01-100
          50190-RP01-200
          100 µg 
          200 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50190-RP02-200
            50190-RP02-50
            50190-RP02-100
            200 µg 
            50 µg 
            100 µg 
            Add to Cart
            ICOSL/ICOS ligand/B7-h2 Background

            Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

            Immune Checkpoint
            Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
            Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

            Immunotherapy   Cancer Immunotherapy   Targeted Therapy

            Human ICOSL/ICOS ligand/B7-h2 References
          • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
          • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
          • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
          • Product nameProduct name
            Size / Price
            Catalog: 11559-MM07-200
            List Price: 
            Price:      (You Save: )

            Datasheet & Documentation

            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"