Anti-ICOS ligand Antibody

Cat: 11559-MM07
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All ICOS ligand Reagents
Anti-ICOS ligand Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-ICOS ligand Antibody
Validated applications
Species reactivity
Reacts with: Human
Human ICOS ligand
No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Recombinant Human ICOS Ligand / B7-H2 / ICOSLG protein (Catalog#11559-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICOS Ligand / B7-H2 / ICOSLG (rh ICOS Ligand / B7-H2 / ICOSLG; Catalog#11559-H08H; NP_056074.1; Met 1-Ser 258). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #4H2B1
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ICOS ligand Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
ELISA(Det) 1:1000-1:10000 This antibody will detect Human ICOSL / ICOS ligand / B7-h2 in ELISA pair set (Catalog: # SEK11559). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 11559-MM05).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ICOS ligand Antibody Alternative Names
Anti-B7-h2 Antibody;Anti-B7H2 Antibody;Anti-B7RP-1 Antibody;Anti-B7RP1 Antibody;Anti-CD275 Antibody;Anti-GL50 Antibody;Anti-ICOS ligand Antibody;Anti-ICOS-L Antibody;Anti-ICOSL Antibody;Anti-ICOSLG Antibody;Anti-LICOS Antibody
ICOS ligand Background Information

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
inducible T-cell co-stimulator ligand
  • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
  • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
  • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 50190-RP02
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 50190-RP01
    Anti-ICOS ligand Antibody (PE) Mouse Monoclonal FCM 11559-MM01-P
    Anti-ICOS ligand Antibody Mouse Monoclonal ELISA(Cap) 11559-MM05
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 11559-RP02
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 11559-RP01
    Anti-ICOS ligand Antibody (FITC) Rabbit Monoclonal FCM 11559-R101-F
    Anti-ICOS ligand Antibody Mouse Monoclonal FCM 11559-MM01
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 11559-T16
    Anti-ICOS ligand Antibody (FITC) Mouse Monoclonal FCM 11559-MM01-F
    Anti-ICOS ligand Antibody (APC) Mouse Monoclonal FCM 11559-MM01-A
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