Anti-ICOS ligand Antibody

Cat: 11559-RP01
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Anti-ICOS ligand Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-ICOS ligand Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human ICOS ligand
Immunogen
Recombinant Human ICOSLG protein (Catalog#11559-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human ICOSLG (rh ICOSLG; Catalog#11559-H08H; NP_056074.1; Met 1-Ser 258). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ICOS ligand Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ICOS ligand Antibody Alternative Names
Anti-B7-h2 Antibody;Anti-B7H2 Antibody;Anti-B7RP-1 Antibody;Anti-B7RP1 Antibody;Anti-CD275 Antibody;Anti-GL50 Antibody;Anti-ICOS ligand Antibody;Anti-ICOS-L Antibody;Anti-ICOSL Antibody;Anti-ICOSLG Antibody;Anti-LICOS Antibody
ICOS ligand Background Information

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
inducible T-cell co-stimulator ligand
References
  • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
  • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
  • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 50190-RP02
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 50190-RP01
    Anti-ICOS ligand Antibody (PE) Mouse Monoclonal FCM 11559-MM01-P
    Anti-ICOS ligand Antibody Mouse Monoclonal ELISA(Cap) 11559-MM05
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 11559-RP02
    Anti-ICOS ligand Antibody (FITC) Rabbit Monoclonal FCM 11559-R101-F
    Anti-ICOS ligand Antibody Mouse Monoclonal FCM 11559-MM01
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 11559-T16
    Anti-ICOS ligand Antibody (FITC) Mouse Monoclonal FCM 11559-MM01-F
    Anti-ICOS ligand Antibody (APC) Mouse Monoclonal FCM 11559-MM01-A
    Anti-ICOS ligand Antibody Mouse Monoclonal ELISA,ELISA(Det) 11559-MM07
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