Anti-ICOS ligand Antibody

Cat: 50190-RP02

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All ICOS ligand Reagents
Anti-ICOS ligand Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-ICOS ligand Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse ICOS ligand
Recombinant Mouse B7H2 protein (Catalog#50190-M08H)
Produced in rabbits immunized with purified, recombinant Mouse B7H2 extracellular domain (rM B7H2; Catalog#50190-M08H; NP_056605.1; Met 1-Lys 279). B7H2 specific IgG was purified by mouse B7H2 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ICOS ligand Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

ICOS ligand Background Information

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
inducible T-cell co-stimulator ligand
  • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
  • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
  • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 50190-RP01
    Anti-ICOS ligand Antibody (PE) Mouse Monoclonal FCM 11559-MM01-P
    Anti-ICOS ligand Antibody Mouse Monoclonal ELISA(Cap) 11559-MM05
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 11559-RP02
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 11559-RP01
    Anti-ICOS ligand Antibody (FITC) Rabbit Monoclonal FCM 11559-R101-F
    Anti-ICOS ligand Antibody Mouse Monoclonal FCM 11559-MM01
    Anti-ICOS ligand Antibody Rabbit Polyclonal ELISA 11559-T16
    Anti-ICOS ligand Antibody (FITC) Mouse Monoclonal FCM 11559-MM01-F
    Anti-ICOS ligand Antibody (APC) Mouse Monoclonal FCM 11559-MM01-A
    Anti-ICOS ligand Antibody Mouse Monoclonal ELISA,ELISA(Det) 11559-MM07
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