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ICOS Ligand / B7-H2 / ICOSLG Antibody, Rabbit PAb

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Mouse B7-H2/ICOSLG Antibody Product Information
Immunogen:Recombinant Mouse B7H2 protein (Catalog#50190-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse B7H2 extracellular domain (rM B7H2; Catalog#50190-M08H; NP_056605.1; Met 1-Lys 279). Total IgG was purified by Protein A affinity chromatography .
Mouse B7-H2/ICOSLG Antibody Usage Guide
Specificity:Mouse B7H2 / ICOSLG / ICOSL / CD275
Application:ELISA

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse B7H2. The detection limit for Mouse B7H2 is 0.00975 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other B7-H2/ICOSLG Antibody Products
Reactivity: Human  
Application: FCM  
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11559-MM01-F-100
11559-MM01-F-50
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Reactivity: Human  
Application: FCM  
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11559-MM01-P-100
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Reactivity: Human  
Application: FCM  
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11559-MM01-A-100
11559-MM01-A-50
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Reactivity: Human  
Application: ELISA  
    11559-RP01-400
    11559-RP01-100
    11559-RP01-200
     
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    Reactivity: Human  
    Application: ELISA  
      11559-RP02-200
      11559-RP02-50
      11559-RP02-100
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      Reactivity: Human  
      Application: ELISA  
        11559-MM07-200
        11559-MM07-50
        11559-MM07-100
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        50 µg 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
        11559-R101-F-50
        11559-R101-F-100
        50 Tests 
        100 Tests 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
        11559-MM01-50
        11559-MM01-200
        11559-MM01-100
        50 µg 
        200 µg 
        100 µg 
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        Reactivity: Mouse  
        Application: ELISA  
          50190-RP02-200
          50190-RP02-50
          50190-RP02-100
          200 µg 
          50 µg 
          100 µg 
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          ICOSL/ICOS ligand/B7-h2 Background

          Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

          Mouse ICOSL/ICOS ligand/B7-h2 References
        • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
        • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
        • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
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          Size / Price
          Catalog: 50190-RP01-100
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          Size:
          100 µg
          200 µg
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          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"