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ICOSL/ICOS ligand/B7-h2 Rabbit PAb

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    Mouse B7-H2/ICOSLG Antibody Product Information
    Immunogen:Recombinant Mouse B7H2 protein (Catalog#50190-M08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse B7H2 extracellular domain (rM B7H2; Catalog#50190-M08H; NP_056605.1; Met 1-Lys 279). Total IgG was purified by Protein A affinity chromatography .
    Other B7-H2/ICOSLG Antibody Products
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    11559-MM01-F-100
    11559-MM01-F-50
    100 Tests 
    50 Tests 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    11559-MM01-P-100
    11559-MM01-P-50
    100 Tests 
    50 Tests 
    Add to Cart
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    11559-MM01-A-100
    11559-MM01-A-50
    100 Tests 
    50 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      11559-RP01-400
      11559-RP01-100
      11559-RP01-200
       
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        11559-RP02-200
        11559-RP02-50
        11559-RP02-100
        200 µg 
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          11559-MM07-200
          11559-MM07-50
          11559-MM07-100
          200 µg 
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          11559-R101-F-50
          11559-R101-F-100
          50 Tests 
          100 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          11559-MM01-50
          11559-MM01-200
          11559-MM01-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50190-RP02-200
            50190-RP02-50
            50190-RP02-100
            200 µg 
            50 µg 
            100 µg 
            Add to Cart
            ICOSL/ICOS ligand/B7-h2 Background

            Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.

            Immune Checkpoint
            Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
            Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

            Immunotherapy   Cancer Immunotherapy   Targeted Therapy

            Mouse ICOSL/ICOS ligand/B7-h2 References
          • Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.
          • Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.
          • Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.
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            Catalog: 50190-RP01-100
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            100 µg
            200 µg
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            Datasheet & Documentation

            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"