ICOS / AILIM Protein (CD278 Protein)

Inducible T-cell co-stimulator / Activation-Inducible Lymphocyte Immunomediatory Molecule (Cluster of Differentiation 278)

ICOS / AILIM Products

ICOS / AILIM Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
ICOS/AILIM/CD278	Human	ICOS/AILIM/CD278/Fc Protein, Recombinant	10344-H03H
ICOS/AILIM/CD278	Mouse	ICOS / AILIM / CD278 Protein, Recombinant	50466-M02H

10344-H03H: Immobilized human human B7-H2 at 1 µg/ml (100 µl/well) can bind human ICOS with a linear range of 1.6-200 ng/ml. Measured by its binding ability in a functional ELISA.

ICOS / AILIM cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
ICOS/AILIM/CD278	Human	Homo sapiens ICOS/AILIM/CD278 cDNA Clone	HG10344-M

ICOS / AILIM Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>ICOS/AILIM/CD278

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Antigen Recognition>>ICOS/AILIM/CD278

ICOS / AILIM Alternative Names

ICOS, AILIM, CD278, MGC39850 [Homo sapiens]

Icos, AILIM, CH29-120A16.4, H4, Ly115, CCLP, CRP-1 [Mus musculus]

ICOS / AILIM Background

Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.

ICOS / AILIM Related Studies

Coyle AJ, et al. (2004) The role of ICOS and other costimulatory molecules in allergy and asthma. Springer Semin Immunopathol. 25(3-4): 349-59.
Chen YQ, et al. (2006) CD28/CTLA-4--CD80/CD86 and ICOS--B7RP-1 costimulatory pathway in bronchial asthma. Allergy. 61(1): 15-26.
van Berkel ME, et al. (2006) CD28 and ICOS: similar or separate costimulators of T cells Immunol Lett. 105(2): 115-22.