|Datasheet||Specific References||Reviews||Related Products||Protocols|
|ORF Clone of Homo sapiens intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) DNA.|
|LW, CD242, ICAM4|
|Identical with the Gene Bank Ref. ID sequence.|
|Whatman FTA elute card (Cat: WB120410) contains 5-10 μg of plasmid.|
|The Whatman FTA elute card can be stored at room temperature for three months under dry condition.|
The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.
The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.
|Human ICAM4 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged||HG13327-G-F|
|Human ICAM4 Gene cDNA Clone (full-length ORF Clone), expression ready, His-tagged||HG13327-G-H|
|Human ICAM4 Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-tagged||HG13327-G-M|
|Human ICAM4 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged||HG13327-G-N|
|Human ICAM4 Gene cDNA Clone (full-length ORF Clone), expression ready, HA-tagged||HG13327-G-Y|
|Product name||Product name|
ICAM4, also known as CD242, is a member of the?immunoglobulin superfamily, ICAM family. ICAM4 contains 2?Ig-like C2-type (immunoglobulin-like) domains. It is similar to the intercellular adhesion molecule (ICAM) protein family. ICAM4 binds to the leukocyte adhesion LFA-1 protein. ICAM4's first reported receptors were CD11a/CD18 and CD11b/CD18. ICAM4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM4 demonstrated that both its domains contain binding sites for CD11c/CD18. CD11c/CD18 is expressed on macrophages in spleen and bone marrow. Inhibition of erythrophagocytosis by anti-ICAM4 and anti-integrin antibodies suggests a role for these interactions in removal of senescent red cells.