All ICAM4 reagents are produced in house and quality controlled, including 13 ICAM4 Gene, 1 ICAM4 Lysate, 1 ICAM4 Protein, 1 ICAM4 qPCR. All ICAM4 reagents are ready to use.
Recombinant ICAM4 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc.
ICAM4cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ICAM4 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
ICAM4, also known as CD242, is a member of the?immunoglobulin superfamily, ICAM family. ICAM4 contains 2?Ig-like C2-type (immunoglobulin-like) domains. It is similar to the intercellular adhesion molecule (ICAM) protein family. ICAM4 binds to the leukocyte adhesion LFA-1 protein. ICAM4's first reported receptors were CD11a/CD18 and CD11b/CD18. ICAM4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM4 demonstrated that both its domains contain binding sites for CD11c/CD18. CD11c/CD18 is expressed on macrophages in spleen and bone marrow. Inhibition of erythrophagocytosis by anti-ICAM4 and anti-integrin antibodies suggests a role for these interactions in removal of senescent red cells.