ICAM-2 Protein & Antibody (CD102)

Intercellular Adhesion Molecule 2 (Cluster of Differentiation 102)

ICAM-2 Products

ICAM-2 Protein, Recombinant

Molecule	Species	Description	Cat. No
ICAM-2/CD102	Human	ICAM-2/CD102/Fc Protein, Recombinant	10332-H03H
ICAM-2/CD102	Human	ICAM-2/CD102 Protein, Recombinant	10332-H08H
ICAM-2/CD102	Mouse	ICAM-2/CD102/Fc Protein, Recombinant	50644-M02H

  10332-H03H:  When cells are added to ICAM2 coated plates (12.5 µg/mL, 100 µL/well), approximately 50 %-60 % will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of PMA stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.

  10332-H08H:  When cells are added to ICAM2 coated plates (12.5 µg/mL, 100 µL/well), approximately 35 %-45 % will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of PMA stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.

  50644-M02H: When cells are added to mouse ICAM2 coated plates (12.5 µg/mL, 100 µL/well), approximately 25-40% will adhere specifically.Measured by the ability of the immobilized protein to support the adhesion of PMA stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.

ICAM-2 Antibody

Molecule	Application	Description	Cat. No
Human ICAM-2/CD102	WB, ELISA	ICAM-2 / CD102 Antibody	10332-MM01
Human ICAM-2/CD102	WB, ELISA	ICAM-2 / CD102 Antibody	10332-RP01
Human ICAM-2/CD102	WB, ELISA	ICAM-2 / CD102 Antibody (Antigen Affinity Purified)	10332-RP02
Human ICAM-2/CD102	WB, ELISA	ICAM-2/CD102 Antibody, Rabbit MAb	10332-R041

ICAM-2 cDNA Clone

Molecule	Species	Description	Cat. No
ICAM-2/CD102	Human	Homo sapiens ICAM-2 /CD102 transcript variant 5 cDNA Clone(NM_000873.3)	HG10332-M
ICAM-2/CD102	Mouse	Mus musculus ICAM-2/CD102 cDNA Clone	MG50644-M
ICAM-2/CD102	Rat	ICAM2 cDNA Clone / ORF Clone	RG80239-G

ICAM-2 Related Areas

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ICAM-2/CD102

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>ICAM-2/CD102

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ICAM-2/CD102

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>ICAM-2/CD102

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>ICAM-2/CD102

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>ICAM-2/CD102

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Pathogen Recognition/Uptake>>ICAM-2/CD102

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Basophils / Eosinophils / Granulocyte Markers / Neutrophils>>ICAM-2/CD102

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>ICAM-2/CD102

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>ICAM-2/CD102

ICAM-2 Alternative Names

ICAM-2, CD102, ICAM2 [Homo sapiens]

Icam-2, CD102, Icam2, RP23-418O11.10-001, Ly-60 [Mus musculus]

ICAM-2 Background

Intercellular adhesion molecule 2 (ICAM-2, CD102), belongs to the ICAM family consisting of three members identified as ligands for integrin receptors. It is a type I transmembrane glycoprotein with two Ig-like C2-type domains, and binds to the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). As a second ligand of leukocyte function-associated antigen-1, ICAM-2 functions as a costimulatory molecule for effector cells. ICAM-2 is mainly expressed on vascular endothelial and hematopoietic cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relation with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in diagnosis of trichinosis recent infections, and in monitoring the prognosis and response to treatment.

ICAM-2 Related Studies

1. Weber KS, et al. (2004) Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN. Inflammation. 28(4): 177-88.
2. Tanaka H, et al. (2004) ICAM-2 gene therapy for peritoneal dissemination of scirrhous gastric carcinoma. Clin Cancer Res. 10(14): 4885-92.
3. Younis AI, et al. (2005) Intercellular adhesion molecule-2 (ICAM-2) in experimental trichinosis. J Egypt Soc Parasitol. 35(3): 1019-26.