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ICAM-1/CD54  Protein, Antibody, ELISA Kit, cDNA Clone

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Expression host: Human Cells  
10346-H03H-50
10346-H03H-100
50 µg 
100 µg 
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Expression host: Human Cells  
10346-HCCH-50
10346-HCCH-100
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100 µg 
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Expression host: Human Cells  
10346-H08H-50
10346-H08H-20
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20 µg 
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Expression host: Human Cells  
50440-M03H-50
50440-M03H-100
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100 µg 
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Description: Active  
Expression host: Human Cells  
50440-M08H-50
50440-M08H-20
50 µg 
20 µg 
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Expression host: Human Cells  
80022-R02H-50
80022-R02H-100
50 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
80022-R08H-50
80022-R08H-100
50 µg 
100 µg 
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  • Slide 1

ICAM-1/CD54 Related Area

ICAM-1/CD54 Related Pathways

    ICAM-1/CD54 Summary & Protein Information

    ICAM-1/CD54 Background

    Gene Summary: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
    General information above from NCBI
    Subunit structure: Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:12526797, ECO:0000269|PubMed:15099525, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:9539703, ECO:0000305}.
    Subcellular location: Membrane; Single-pass type I membrane protein.
    Post-translational: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
    Sequence similarity: Belongs to the immunoglobulin superfamily. ICAM family. {ECO:0000305}.; Contains 5 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

    ICAM-1/CD54 Alternative Name

    BB2,CD54,P3.58, [homo-sapiens]
    BB2,CD54,ICAM1,ICAM-1,P3.58, [human]
    CD54,Icam1,Icam-1,Ly-47,MALA-2,MGC6195,myD10, [mouse]
    CD54,Ly-47,Icam-1,MALA-2, [mus-musculus]

    ICAM-1/CD54 Related Studies

  • Xu H, et al. (2001) The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol. 31(10): 3085-93.
  • Terol MJ, et al. (2003) Soluble intercellular adhesion molecule-1 (s-ICAM-1/s-CD54) in diffuse large B-cell lymphoma: association with clinical characteristics and outcome. Ann Oncol. 14(3): 467-74.
  • Mendez MP, et al. (2006) Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 290(5): L962-70.
  • Lawson C, et al. (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep. 61(1): 22-32.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"