ICAM-1 Protein & Antibody (CD54)

Intercellular Adhesion Molecule 1 (Cluster of Differentiation 54)

ICAM-1 Products

ICAM-1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ICAM-1/CD54	Human	ICAM-1/CD54/Fc Protein, Recombinant	10346-H03H
ICAM-1/CD54	Human	ICAM-1/CD54 Protein, Recombinant	10346-H08H
ICAM-1/CD54	Human	ICAM-1/CD54 Protein, Recombinant	10346-HCCH
ICAM-1/CD54	Mouse	ICAM-1/CD54 Protein, Recombinant	50440-M03H
ICAM-1/CD54	Mouse	ICAM-1/CD54 Protein, Recombinant	50440-M08H
ICAM-1/CD54	Rat	ICAM-1/CD54 Protein, Recombinant	80022-R08H

10346-H03H: When cells are added to ICAM1 coated plates (12.5 µg/mL, 100 µL/well), approximately 55%-65% will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of PMA stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.

10346-H08H: When cells are added to ICAM1 coated plates (12.5 µg/mL, 100 µL/well), approximately 20-40% will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of PMA stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.

10346-HCCH: When cells are added to human ICAM1 coated plates (12.5 µg/mL, 100 µL/well), approximately 20-40% will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of PMA stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.

50440-M03H: When cells are added to ICAM1 coated plates (12.5 µg/mL, 100 µL/well), approximately 60%-70% will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of PMA stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.

50440-M08H: When cells are added to ICAM1 coated plates (12.5 µg/mL, 100 µL/well), approximately 40%-50% will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of PMA stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.

80022-R08H: When cells are added to rat ICAM1 coated plates (12.5 µg/mL, 100 µL/well), approximately 20-40% will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of PMA stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.

ICAM-1 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human ICAM-1/CD54	FCM	ICAM1 / CD54 Antibody	10346-MM01
Human ICAM-1/CD54	WB	Mouse Monoclonal Antibody	10346-MM03
Human ICAM-1/CD54	ELISA	Mouse Monoclonal Antibody	10346-MM04
Human ICAM-1/CD54	FCM	ICAM-1 / CD54 Antibody ( FITC )	10346-MM01-F
Human ICAM-1/CD54	WB, ELISA	Rabbit Polyclonal Antibody	10346-RP01
Human ICAM-1/CD54	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10346-RP02
Human ICAM-1/CD54	WB, ELISA	Rabbit Monoclonal Antibody	10346-R013
Mouse ICAM-1/CD54	WB, ELISA	Rabbit Polyclonal Antibody	50440-RP01
Mouse ICAM-1/CD54	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50440-RP02
Mouse ICAM-1/CD54	WB, FCM	CD54 / ICAM1 Antibody ( FITC )	50440-R009-F
Rat ICAM-1/CD54	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	80022-RP02
Rat ICAM-1/CD54	ELISA	ICAM-1 / CD54 Antibody	80022-MM11
Rat ICAM-1/CD54	WB	ICAM-1 / CD54 Antibody	80022-MM12

ICAM-1 ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human ICAM-1/CD54	ELISA	ICAM-1/CD54 ELISA Kit	SEK10398

ICAM-1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ICAM-1/CD54	Human	Homo sapiens ICAM-1/CD54 cDNA Clone(NM_000201.2)	HG10346-M
ICAM-1/CD54	Mouse	Mus musculus ICAM-1/CD54 cDNA Clone	MG50440-M
ICAM-1/CD54	Rat	Rattus norvegicus ICAM-1/CD54 cDNA Clone	RG80022-M

ICAM-1 Related Areas

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ICAM-1/CD54

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>ICAM-1/CD54

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ICAM-1/CD54

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell / T Cell Migration/Adhesion>>ICAM-1/CD54

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>ICAM-1/CD54

Immunology>>Cluster of Differentiation>>ICAM-1/CD54

ICAM-1 Alternative Names

ICAM-1, ICAM1, CD54, BB2, P3.58 [Homo sapiens]

Icam-1, Icam1, CD54, Ly-47, MALA-2, MGC6195, myD10 [Mus musculus]

ICAM-1 Background

Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

ICAM-1 Related Studies

Xu H, et al. (2001) The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol. 31(10): 3085-93.
Terol MJ, et al. (2003) Soluble intercellular adhesion molecule-1 (s-ICAM-1/s-CD54) in diffuse large B-cell lymphoma: association with clinical characteristics and outcome. Ann Oncol. 14(3): 467-74.
Mendez MP, et al. (2006) Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 290(5): L962-70.
Lawson C, et al. (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep. 61(1): 22-32.

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