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ICAM-1/CD54 Mouse MAb

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    Rat ICAM1 Antibody Product Information
    Immunogen:Recombinant Rat ICAM-1 / CD54 protein (Catalog#80022-R08H)
    Clone ID:2D7E7
    Ig Type:Mouse IgG1
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat ICAM-1 / CD54 (rR ICAM-1 / CD54; Catalog#80022-R08H; Q00238-1; Met 1-Thr 493). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
    Other ICAM1 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10346-RP01-100
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      10346-RP01-400
      100 µg 
      200 µg 
       
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      Reactivity: Human  
      Application: ELISA  WB  IHC-P  IP  
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      10346-RP02-50
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      Reactivity: Human  
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      • Slide 1
      10346-MM03-50
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      10346-MM03-200
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      100 µg 
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      Reactivity: Human  
      Application: ELISA  
        10346-MM04-50
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        Reactivity: Human  
        Application: ELISA  
          10346-R013-50
          10346-R013-100
          50 µg 
          100 µg 
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          Reactivity: Human  
          Application: ELISA  FCM  IF  ICC/IF  
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          10346-MM01-50
          10346-MM01-100
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          50 µg 
          100 µg 
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          Reactivity: Human  
          Application: FCM  
          • Slide 1
          • Slide 1
          10346-MM01-F-50
          10346-MM01-F-100
          50 Tests 
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          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10346-MM01-P-50
          10346-MM01-P-100
          50 Tests 
          100 Tests 
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          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10346-MM01-A-100
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          Reactivity: Mouse  
          Application: FCM  
          • Slide 1
          50440-R009-100
          50440-R009-50
          100 µg 
          50 µg 
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          Reactivity: Mouse  
          Application: ELISA  
            50440-RP01-100
            50440-RP01-200
            50440-RP01-400
            100 µg 
            200 µg 
             
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  IHC-P  
            • Slide 1
            50440-RP02-50
            50440-RP02-100
            50440-RP02-200
            50 µg 
            100 µg 
            200 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: FCM  
            • Slide 1
            50440-R009-F-50
            50440-R009-F-100
            50 Tests 
            100 Tests 
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            Reactivity: Mouse  
            Application: ELISA  IHC-P  
            • Slide 1
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            50440-R020-50
            50440-R020-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: FCM  
            • Slide 1
            50440-R009-P-50
            50440-R009-P-100
            50 Tests 
            100 Tests 
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            Reactivity: Rat  
            Application: ELISA  
              80022-R143-50
              80022-R143-100
              50 µg 
              100 µg 
              Add to Cart
              Reactivity: Rat  
              Application: IF  ICC/IF  
              • Slide 1
              80022-R037-100
              80022-R037-50
              100 µg 
              50 µg 
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              Reactivity: Rat  
              Application: FCM  
              • Slide 1
              80022-R037-F-100
              80022-R037-F-50
              100 Tests 
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              Reactivity: Rat  
              Application: FCM  
              • Slide 1
              80022-R037-P-100
              80022-R037-P-50
              100 Tests 
              50 Tests 
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              Reactivity: Rat  
              Application: ELISA  IP  
              • Slide 1
              80022-RP02-50
              80022-RP02-100
              80022-RP02-200
              50 µg 
              100 µg 
              200 µg 
              Add to Cart
              Reactivity: Rat  
              Application: ELISA  
                80022-RP01-100
                80022-RP01-200
                80022-RP01-400
                100 µg 
                200 µg 
                 
                Add to Cart
                Reactivity: Rat  
                Application: FCM  
                • Slide 1
                80022-R037-A-50
                80022-R037-A-100
                50 Tests 
                100 Tests 
                Add to Cart
                Reactivity: Rat  
                Application: IHC-P  
                • Slide 1
                • Slide 1
                80022-MM01-100
                80022-MM01-50
                80022-MM01-200
                100 µg 
                50 µg 
                200 µg 
                Add to Cart
                Reactivity: Rat  
                Application: IHC-P  
                • Slide 1
                80022-R003-100
                80022-R003-50
                100 µg 
                50 µg 
                Add to Cart

                Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

                Lane A: NIH3T3 Whole Cell Lysate

                Lane B: Hela Whole Cell Lysate

                Lysates/proteins at 30 μg per lane.

                Secondary

                Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

                Developed using the ECL technique.

                Performed under reducing conditions.

                Predicted band size:15 kDa

                Observed band size:17 kDa

                ICAM-1/CD54 Background

                Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

                Rat ICAM-1/CD54 References
              • Xu H, et al. (2001) The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol. 31(10): 3085-93.
              • Terol MJ, et al. (2003) Soluble intercellular adhesion molecule-1 (s-ICAM-1/s-CD54) in diffuse large B-cell lymphoma: association with clinical characteristics and outcome. Ann Oncol. 14(3): 467-74.
              • Mendez MP, et al. (2006) Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 290(5): L962-70.
              • Lawson C, et al. (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep. 61(1): 22-32.
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                Catalog: 80022-MM11-50
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                Datasheet & Documentation

                All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"