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ICAM-1 / CD54 Antibody, Rabbit PAb

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Mouse ICAM1 Antibody Product Information
Immunogen:Recombinant Mouse ICAM-1 protein (Catalog#50440-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse ICAM1 / CD54 (rM ICAM-1; Catalog#50440-M08H; NP_034623.1; Met 1-Asn 485). Total IgG was purified by Protein A affinity chromatography.
Mouse ICAM1 Antibody Usage Guide
Specificity:Mouse ICAM-1 / CD54
Application:ELISA

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse ICAM1. The detection limit for Mouse ICAM1 is 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other ICAM1 Antibody Products
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        Reactivity: Human  
        Application: ELISA  FCM  IF  ICC/IF  
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        10346-MM01-P-50
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        50440-RP02-50
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        Application: FCM  
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        50440-R020-50
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        Reactivity: Mouse  
        Application: FCM  
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          Reactivity: Rat  
          Application: ELISA  IP  
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          80022-RP02-50
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          100 µg 
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          Application: ELISA  
            80022-MM11-50
            80022-MM11-100
            80022-MM11-200
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            100 µg 
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              80022-RP01-100
              80022-RP01-200
              80022-RP01-400
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              200 µg 
               
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              Reactivity: Rat  
              Application: FCM  
              • Slide 1
              80022-R037-A-50
              80022-R037-A-100
              50 Tests 
              100 Tests 
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              Reactivity: Rat  
              Application: IHC-P  
              • Slide 1
              • Slide 1
              80022-MM01-100
              80022-MM01-50
              80022-MM01-200
              100 µg 
              50 µg 
              200 µg 
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              Reactivity: Rat  
              Application: IHC-P  
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              80022-R003-100
              80022-R003-50
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              ICAM-1/CD54 Background

              Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

              Mouse ICAM-1/CD54 References
            • Xu H, et al. (2001) The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol. 31(10): 3085-93.
            • Terol MJ, et al. (2003) Soluble intercellular adhesion molecule-1 (s-ICAM-1/s-CD54) in diffuse large B-cell lymphoma: association with clinical characteristics and outcome. Ann Oncol. 14(3): 467-74.
            • Mendez MP, et al. (2006) Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 290(5): L962-70.
            • Lawson C, et al. (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep. 61(1): 22-32.
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              Catalog: 50440-RP01-100
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              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"