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ICAM-1/CD54 Mouse MAb

  • ICAM-1 / CD54 Antibody, Mouse MAb, Western blot
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Human ICAM1 Antibody Product Information
Immunogen:Recombinant Human ICAM-1 protein (Catalog#10346-H08H)
Clone ID:8H8G9
Ig Type:Mouse IgG1
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICAM1 / CD54 extracellular domain (rh ICAM1; Catalog#10346-H08H; NP_000192.2; Met 1-Glu 480). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human ICAM1 Antibody WB Application Image
Other ICAM1 Antibody Products
Reactivity: Human  
Application: ELISA  
    10346-RP01-100
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    10346-RP01-400
    100 µg 
    200 µg 
     
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    Reactivity: Human  
    Application: ELISA  WB  IHC-P  IP  
    • Slide 1
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    10346-RP02-50
    10346-RP02-100
    10346-RP02-200
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    100 µg 
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    Reactivity: Human  
    Application: ELISA  
      10346-MM04-50
      10346-MM04-100
      10346-MM04-200
      50 µg 
      100 µg 
      200 µg 
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      Reactivity: Human  
      Application: ELISA  
        10346-R013-50
        10346-R013-100
        50 µg 
        100 µg 
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        Reactivity: Human  
        Application: ELISA  FCM  IF  ICC/IF  
        • Slide 1
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        10346-MM01-50
        10346-MM01-100
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        50 µg 
        100 µg 
        200 µg 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
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        10346-MM01-F-50
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        Reactivity: Human  
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        • Slide 1
        10346-MM01-P-50
        10346-MM01-P-100
        50 Tests 
        100 Tests 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10346-MM01-A-100
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        100 Tests 
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        Reactivity: Mouse  
        Application: FCM  
        • Slide 1
        50440-R009-100
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        100 µg 
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        Reactivity: Mouse  
        Application: ELISA  
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          100 µg 
          200 µg 
           
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          Reactivity: Mouse  
          Application: ELISA  IHC-P  
          • Slide 1
          50440-RP02-50
          50440-RP02-100
          50440-RP02-200
          50 µg 
          100 µg 
          200 µg 
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          Reactivity: Mouse  
          Application: FCM  
          • Slide 1
          50440-R009-F-50
          50440-R009-F-100
          50 Tests 
          100 Tests 
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          Reactivity: Mouse  
          Application: ELISA  IHC-P  
          • Slide 1
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          50440-R020-50
          50440-R020-100
          50 µg 
          100 µg 
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          Reactivity: Mouse  
          Application: FCM  
          • Slide 1
          50440-R009-P-50
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          50 Tests 
          100 Tests 
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          Reactivity: Rat  
          Application: ELISA  
            80022-R143-50
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            50 µg 
            100 µg 
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            Reactivity: Rat  
            Application: IF  ICC/IF  
            • Slide 1
            80022-R037-100
            80022-R037-50
            100 µg 
            50 µg 
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            Reactivity: Rat  
            Application: FCM  
            • Slide 1
            80022-R037-F-100
            80022-R037-F-50
            100 Tests 
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            Reactivity: Rat  
            Application: FCM  
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            100 Tests 
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            Reactivity: Rat  
            Application: ELISA  IP  
            • Slide 1
            80022-RP02-50
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            80022-RP02-200
            50 µg 
            100 µg 
            200 µg 
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            Reactivity: Rat  
            Application: ELISA  
              80022-MM11-50
              80022-MM11-100
              80022-MM11-200
              50 µg 
              100 µg 
              200 µg 
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              Reactivity: Rat  
              Application: ELISA  
                80022-RP01-100
                80022-RP01-200
                80022-RP01-400
                100 µg 
                200 µg 
                 
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                Reactivity: Rat  
                Application: FCM  
                • Slide 1
                80022-R037-A-50
                80022-R037-A-100
                50 Tests 
                100 Tests 
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                Reactivity: Rat  
                Application: IHC-P  
                • Slide 1
                • Slide 1
                80022-MM01-100
                80022-MM01-50
                80022-MM01-200
                100 µg 
                50 µg 
                200 µg 
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                Reactivity: Rat  
                Application: IHC-P  
                • Slide 1
                80022-R003-100
                80022-R003-50
                100 µg 
                50 µg 
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                ICAM-1/CD54 Background

                Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

                Human ICAM-1/CD54 References
              • Xu H, et al. (2001) The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol. 31(10): 3085-93.
              • Terol MJ, et al. (2003) Soluble intercellular adhesion molecule-1 (s-ICAM-1/s-CD54) in diffuse large B-cell lymphoma: association with clinical characteristics and outcome. Ann Oncol. 14(3): 467-74.
              • Mendez MP, et al. (2006) Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 290(5): L962-70.
              • Lawson C, et al. (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep. 61(1): 22-32.
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                Catalog: 10346-MM03-50
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                Datasheet & Documentation

                All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"