I-309 / CCL1 Protein (TCA-3 Protein)

Chemokine (C-C motif) Ligand 1 (T-cell activation protein 3)

I-309 / CCL1 Products

I-309 / CCL1 Protein, Recombinant

Molecule	Species	Description	Cat. No
I-309/CCL1/TCA-3	Human	I-309/CCL1/TCA-3/Fc Protein, Recombinant	10057-H01H
I-309/CCL1/TCA-3	Mouse	CCL1 / I-309 / TCA3 Protein, Recombinant	50178-M01H

I-309 / CCL1 cDNA Clone

Molecule	Species	Description	Cat. No
I-309/CCL1/TCA-3	Human	Homo sapiens I-309/CCL1/TCA-3 cDNA Clone(NM_002981.1)	HG10057-M
I-309/CCL1/TCA-3	Mouse	Mus musculus I-309/CCL1/TCA-3 cDNA Clone	MG50178-M

I-309 / CCL1 Related Areas

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>I-309/CCL1/TCA-3

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Macrophage Marker>>I-309/CCL1/TCA-3

I-309 / CCL1 Alternative Names

I-309, CCL1, TCA3, P500, SCYA1, SISe [Homo sapiens]

I-309, CCL1, Tca-3, RP23-446K18.2, BF534335, Scya1 [Mus musculus]

I-309 / CCL1 Background

CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309/CCL1/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8, and induces biochemical events that may result in the control of chemotaxis, proliferation, apoptosis and adhesion. It has been demonstrated that I-309/CCL1/TCA-3 displays chemotactic activity for monocytes and other cell types such as NK cells and dendritic cells, but not for neutrophils. Furthermore, as the only known physiological ligand for CCR8, I-309/CCL1/TCA-3 was identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection. I-309/CCL1/TCA-3 induce significant levels of LTC4 from elicited eosinophils.

I-309 / CCL1 Related Studies

1. Miller MD, et al. (1992) The human cytokine I-309 is a monocyte chemoattractant. Proc Natl Acad Sci. 89 (7): 2950-4.
2. Roos RS, et al. (1997) Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem. 272 (28): 17251-4.
3. Oliveira SH, et al. (2002) Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. J Leukoc Biol. 71(6): 1019-25.