Hypertension Therapeutic Targets

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
ADRA1A	ADRA1C, ADRA1L1, ALPHA1AAR
ADRA2B	ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR				HG11293-M
ADRB2	ADRB2R, ADRBR, B2AR, BAR, BETA2AR				HG10378-M
ACE2	UNQ868/PRO1885, ACEH, DKFZp434A014		10108-H02H		HG10108-M MG50249-M
AGTR1	AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R, AT1AR, AT1BR				HG10375-M
Carbonic Anhydrase II	CA2, CA-II, CAII, Car2, CAC				HG10478-M
Carbonic Anhydrase III	CA3, CAIII, Car3, CA-III				HG10503-M
Carbonic Anhydrase IV	CA-IV, CAIV, Car4, RP17	CA4 is a membrane-associated enzyme anchored to plasma membrane surfaces by a phosphatidylinositol glycan linkage. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.	50350-M08H		HG10472-M MG50350-M
Carbonic Anhydrase IX	CAIX, CA9, MN	CA9 is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. Recently, it is also been regarded as a new therapeutic target for CA9-derived carcinomas.	10107-H02H 10107-H08H	10107-R003 10107-RP01 10107-RP02	HG10107-M
Carbonic Anhydrase VIII	CA8, CA-VIII, CALS, CAMRQ3, CARP, MGC120502, MGC99509				HG10063-M
Carbonic Anhydrase X	CA10, CA-RPX, CARPX, HUCEP-15	CA10 belongs to the CA family of zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide in various biological processes such as respiration, renal tubular acidification and bone resorption.	10687-H03H 10687-H08H 10687-HCCH	10687-MM04	HG10687-M
Carbonic Anhydrase XII	CAXII, CA12, FLJ20151, HsT18816	This bitopic membrane protein contains an N-terminal extracellular catalytic domain, a membrane-spanning α-helix, and a small intracellular C-terminal domain. Overexpression of the CA12 is observed in certain human cancers and is used as a tumor marker.	10617-H08H 50014-M08H		HG10617-M MG50014-M
Carbonic Anhydrase XIII	CA13, CAXIII, FLJ37995, MGC59868, CA-XIII	CA XIV is a polypeptide consisting of an extracellular N-terminal catalytic domain, a membrane-spanning segment and a short intracellular C-terminal segment with several potential phosphorylation sites. CA14, together with CA4, play important roles in the regulation of intracellular pH in hippocampal neurons by facilitating AE3-mediated Cl––HCO3- exchange.			HG10461-M
Carbonic Anhydrase XIV	CAXiV, CA14		10458-H08H 50013-M08H		HG10458-M MG50013-M
Carbonic Anhydrase VA	CA5A, CA5, CAV, CAVA, CA-VA				HG10500-M
CD10/Neprilysin	MME, Neutral endopeptidase, NEP, CALLA	Neprilysin, also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), CD10, and common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme, which belongs to the peptidase M13 family. In addition, as a major degrading enzyme of amyloid β peptide (Aβ) in the brain, NEP has been involved in the development of Alzheimer’s disease.	10805-H01H 10805-HNCH 50218-M07H		HG10805-M MG50218-M
Renin 1	D19352, Ren, Ren-1, Ren-A, Ren1c, Ren1d, Rn-1, Rnr	It is a highly specific endopeptidase, belonging to the peptidase A1 family. Its only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.	50279-M08H	50279-RP01	MG50279-M
Renin	FLJ10761, HNFJ2	Renin, also commonly known as Angiotensinogenase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), and plays an essential role in the elevation of blood pressure and increased sodium retention by the kidney. As a highly specific aspartyl proteinase belonging to the peptidase A1 family, the only known physiological substrate of renin is angiotensinogen, which is cleaved at the Leu-Xaa bond to generate angiotensin I.	10969-H08H	10969-RP01	HG10969-M
AGTR2	AT2, ATGR2, MRX88				HG10387-M
ENPEP/CD249	APA, gp160	It is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamaticand aspartatic amino acid residues from the N-terminus of polypeptides. This enzyme encoded by the ENPEP gene degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.			HG10554-M MG50082-M
NPY	PYY4				HG10946-M