TYR cDNA ORF Clone, Human, untagged

Cat: HG13378-UT
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TYR cDNA ORF Clone, Human, untagged General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1134 bp
Description
Full length Clone DNA of Human tyrosinase (oculocutaneous albinism IA).
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-untagged
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

TYR cDNA ORF Clone, Human, untagged Alternative Names
ATN cDNA ORF Clone, Human;CMM8 cDNA ORF Clone, Human;OCA1 cDNA ORF Clone, Human;OCA1A cDNA ORF Clone, Human;OCAIA cDNA ORF Clone, Human;SHEP3 cDNA ORF Clone, Human
TYR Background Information

TYR is a melanosomal membrane-bound glycoprotein with a native molecular weight of 55kD, which increases to 65-75kD following post-translational modification at six potential N-glycosylation sites as it traffics to the mature melanosome. It is the key enzyme for pigmentation that catalyzes the oxidation of its substrates tyrosine and DOPA to form the intermediate DOPAquinone.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tyrosinase
References
  • Jagirdar K, Smit DJ, Ainger SA, et al. Molecular analysis of common polymorphisms within the human Tyrosinase locus and genetic association with pigmentation traits. Pigment cell & melanoma research. 2014;27(4):552-564.
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