|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human TNFRSF21 ORF mammalian expression plasmid, C-GFPSpark tag||HG12171-ACG|
|Human TNFRSF21 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG12171-ACR|
|Human TNFRSF21 ORF mammalian expression plasmid, C-Flag tag||HG12171-CF|
|Human TNFRSF21 ORF mammalian expression plasmid, C-His tag||HG12171-CH|
|Human TNFRSF21 ORF mammalian expression plasmid, C-Myc tag||HG12171-CM|
|Human TNFRSF21 ORF mammalian expression plasmid, C-HA tag||HG12171-CY|
|Human TNFRSF21 Gene cDNA clone plasmid||HG12171-G|
|Human TNFRSF21 ORF mammalian expression plasmid, N-Flag tag||HG12171-NF|
|Human TNFRSF21 ORF mammalian expression plasmid, N-His tag||HG12171-NH|
|Human TNFRSF21 ORF mammalian expression plasmid, N-Myc tag||HG12171-NM|
|Human TNFRSF21 ORF mammalian expression plasmid, N-HA tag||HG12171-NY|
|Human TNFRSF21 natural ORF mammalian expression plasmid||HG12171-UT|
|Learn more about expression Vectors|
TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.