SOCS3 qPCR Primer Pairs, Human

Cat: HP101201
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SOCS3 qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
SOCS3 qPCR Primer Pairs, Human Alternative Names
ATOD4 qPCR Primer Pairs, Human;CIS3 qPCR Primer Pairs, Human;Cish3 qPCR Primer Pairs, Human;SOCS-3 qPCR Primer Pairs, Human;SSI-3 qPCR Primer Pairs, Human;SSI3 qPCR Primer Pairs, Human
SOCS3 Background Information

Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 / CIS3 is involved in negative regulation of cytokines that signal through the JAK / STAT pathway. SOCS3 / CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3 / CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3 / CIS3 regulates IL-6 signaling. SOCS3 / CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3 / CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis.

Full Name
suppressor of cytokine signaling 3
References
  • Hoertner M., et al., 2002, Eur. J. Biochem. 269:2516-26.
  • Yamamoto K., et al., 2003, Biochem. Biophys. Res. Commun. 310 : 1188-93.
  • Kamura T., et al., 2004, Genes Dev. 18:3055-65.
  • Okamura A., et al., 2004, Blood 103:2997-3004.
  • Ekelund E., et al., 2006, Am. J. Hum. Genet. 78:1060-5.
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    SOCS3 qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    SOCS3 cDNA ORF Clone, Human, untagged HG11315-UT
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    SOCS3 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG11315-CF
    SOCS3 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG11315-NF
    SOCS3 cDNA ORF Clone, Human, C-His tag HG11315-CH
    SOCS3 cDNA ORF Clone, Human, N-His tag HG11315-NH
    SOCS3 cDNA ORF Clone, Human, C-HA tag HG11315-CY
    SOCS3 cDNA ORF Clone, Human, N-HA tag HG11315-NY
    SOCS3 cDNA ORF Clone, Human, C-Myc tag HG11315-CM
    SOCS3 cDNA ORF Clone, Human, N-Myc tag HG11315-NM
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