SLAMF8 cDNA ORF Clone, Human, C-His tag General Information
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Human SLAM family member 8 with C terminal His tag.
Enhanced CMV promoter
KpnI + XbaI(6kb+0.9kb)
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
SLAMF8 cDNA ORF Clone, Human, C-His tag Validated Images
SLAMF8 cDNA ORF Clone, Human, C-His tag Alternative Names
BLAME cDNA ORF Clone, Human;CD353 cDNA ORF Clone, Human;SBBI42 cDNA ORF Clone, Human
SLAMF8 Background Information
The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells.
Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.
SLAM family member 8
Kingsbury G.A., et al., 2001, J. Immunol. 166:5675-80. Zhang Z., et al., 2004, Protein Sci. 13: 2819-24. Veillette,A. et al., 2006, Nat Rev Immunol 6 (1): 56-66. Veillette,A. et al., 2006, Trends Immunol 27 (5): 228-34. Yan,Q. et al., 2007, Proc Natl Acad Sci. USA.104 (25):10583-8.