RP2 cDNA ORF Clone, Human, C-HA tag

Cat: HG10637-CY
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RP2 cDNA ORF Clone, Human, C-HA tag General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
1053 bp
Description
Full length Clone DNA of Human retinitis pigmentosa 2 (X-linked recessive) with C terminal HA tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-HA
Tag Sequence
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

RP2 cDNA ORF Clone, Human, C-HA tag Alternative Names
DELXp11.3 cDNA ORF Clone, Human;KIAA0215 cDNA ORF Clone, Human;NM23-H10 cDNA ORF Clone, Human;NME10 cDNA ORF Clone, Human;RP2 cDNA ORF Clone, Human;TBCCD2 cDNA ORF Clone, Human;XRP2 cDNA ORF Clone, Human
RP2 Background Information

XRP2, also known as Protein XRP2 and RP2, is a member of the TBCC (tubulin cofactor C) family and contains one C-CAP/cofactor C-like domain. This protein is encoded by the RP2 gene in humans. XRP2 stimulates the GTPase activity of tubulin, but does not enhance tubulin heterodimerization. XRP2 acts as guanine nucleotide dissociation inhibitor for ARL3. Defects in RP2 gene are the cause of retinitis pigmentosa type 2 (RP2), also known as X-linked retinitis pigmentosa 2 (XLRP-2). It leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. 

Full Name
retinitis pigmentosa 2 (X-linked recessive)
References
  • Schwahn U., et al.,(1998), Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat. Genet. 19:327-332.
  • Ross M.T., et al., (2005), The DNA sequence of the human X chromosome.Nature 434:325-337.
  • Vaca Jacome A.S., et al.,(2015), N-terminome analysis of the human mitochondrial proteome. Proteomics 15:2519-2524.
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