|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Human PTX3 ORF mammalian expression plasmid, C-GFPSpark tag||HG12082-ACG|
|Human PTX3 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG12082-ACR|
|Human PTX3 ORF mammalian expression plasmid, C-Flag tag||HG12082-CF|
|Human PTX3 ORF mammalian expression plasmid, C-His tag||HG12082-CH|
|Human PTX3 ORF mammalian expression plasmid, C-Myc tag||HG12082-CM|
|Human PTX3 ORF mammalian expression plasmid, C-HA tag||HG12082-CY|
|Human PTX3 Gene cDNA clone plasmid||HG12082-G|
|Human PTX3 ORF mammalian expression plasmid, N-Flag tag||HG12082-NF|
|Human PTX3 ORF mammalian expression plasmid, N-His tag||HG12082-NH|
|Human PTX3 ORF mammalian expression plasmid, N-Myc tag||HG12082-NM|
|Human PTX3 ORF mammalian expression plasmid, N-HA tag||HG12082-NY|
|Human PTX3 natural ORF mammalian expression plasmid||HG12082-UT|
|Learn more about expression Vectors|
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein which contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.