**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other.
EPCR cDNA ORF Clone, Rhesus, Related Products
EPCR cDNA ORF Clone, Rat, Related Products
| Product Name | Catalog#(PDF) |
|---|---|
| EPCR cDNA ORF Clone in Cloning Vector, Rat | RG80362-U |
| EPCR Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag | RG80362-ACGLN |
| EPCR qPCR Primer Pairs, Rat | RP300332 |
EPCR cDNA ORF Clone, Mouse, Related Products
EPCR cDNA ORF Clone, Human, Related Products
